RT Journal Article SR Electronic A1 Dowell, Masha T1 Rapid Reperfusion Therapy in Acute Ischemic Stroke Reduces Complications and Improves Outcomes JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 1 SP 16 OP 17 DO 10.1177/155989771401010 UL http://mdc.sagepub.com/content/14/1/16.abstract AB The American Heart Association (AHA)/American Stroke Association (ASA) guidelines recommend a door-to-needle (DTN) time of =60 minutes for reperfusion therapy for acute ischemic stroke patients [Jauch EC et al. Stroke 2013]. The rapid treatment is important for improving stroke outcome, but many studies have concluded that this time frame has been met by <30% of intravenous tissue plasminogen activator (t-PA)-treated stroke patients. This article discusses the principal results from the Target: Stroke Initiative, a national program organized by the AHA/ASA, which addresses this timing dilemma by increasing the proportion of stroke patients with DTN time frames of <60 minutes.