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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EEarly intervention is critical in patients with acute stroke, and there is a narrow time frame in which to pursue acute therapies [Saver JL. \u003Cem\u003EStroke\u003C\/em\u003E 2006; Saver JL et al. \u003Cem\u003EJAMA\u003C\/em\u003E 2013]. Approximately 35% to 70% of patients with stroke arrive by ambulance. This article presents results from the Field Administration of Stroke Therapy\u2014Magnesium (FAST-MAG) trial, a prehospital, multicenter, randomized, placebo-controlled efficacy study whose aim was to test whether intravenous magnesium sulfate given within 2 hours of symptom onset improves the outcomes of patients with acute stroke.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EEarly intervention is critical in patients with acute stroke, and there is a narrow time frame in which to pursue acute therapies [Saver JL. \u003Cem\u003EStroke\u003C\/em\u003E 2006; Saver JL et al. \u003Cem\u003EJAMA\u003C\/em\u003E 2013]. Approximately 35% to 70% of patients with stroke arrive by ambulance. Therefore, prehospital personnel are often the first health care providers to come in contact with these patients [Ekundayo OJ et al. \u003Cem\u003ECirc Cardiovasc Qual Outcomes\u003C\/em\u003E 2013]. Jeffrey L. Saver, MD, University of California Los Angeles Stroke Center, Los Angeles, California, USA, presented results from the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) trial, a prehospital, multicenter, randomized, placebo-controlled efficacy study whose aim was to test whether intravenous magnesium sulfate given within 2 hours of symptom onset improves the outcomes of patients with acute stroke. Although the researchers did not show that the administration of prehospital magnesium sulfate improved neurologic outcomes in patients with acute stroke, they did show that it was feasible to test a potential neuroprotective agent within the first 2 hours of stroke onset (with treatment being initiated in 74% of patients \u00a31 hour after symptom onset).\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EAccording to Dr. Saver, magnesium sulfate is known to dilate cerebral blood vessels, increase blood flow to the brain, and block calcium buildup in neurons [Kemp PA et al. \u003Cem\u003EClinic Sci (Lond)\u003C\/em\u003E 1993; Alborch et al. \u003Cem\u003EEur J Pharmacol\u003C\/em\u003E 1992]. In animal models, magnesium has demonstrated a modest protective effect against stroke, and it has an established safety record in humans [Muir KW. \u003Cem\u003ECNS Drugs\u003C\/em\u003E 2001].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe study involved collaboration among 40 emergency medical service agencies, 315 ambulances, 2988 paramedics, 60 receiving hospitals, 952 participating emergency physicians, and \u0026gt;225 neurologists and neurosurgeons throughout Los Angeles and Orange counties.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe study randomized 1700 patients who were within 2 hours of stroke symptom onset to either a loading dose (4 g over 15 minutes) of magnesium sulfate or matched saline placebo in the ambulance. On arrival at the emergency department, a maintenance infusion (16 g) of magnesium sulfate or matched saline placebo was continued over the next 24 hours.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EParticipants had a mean age of 69 years (range, 40\u201395 years), and 42% were women. The median pretreatment stroke severity score on the Los Angeles Motor Scale was 4. The final diagnosis was cerebral ischemia in 73%, intracerebral hemorrhage in 23%, and stroke mimic in 3.9%. Overall, 74% of patients were treated in the golden hour and 25% in the second hour. Median time to treatment was 48 minutes after symptom onset.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe primary study endpoint was having a modified Rankin Scale score of 0 to 6, measured at 90 days. The study showed no statistically significant difference in the degree of disability on the modified Rankin Scale between the 2 treatment groups. Administration of intravenous magnesium sulfate was a safe intervention, with no increase in bradycardia and mild increases in hypertension and respiratory distress. Overall, there was no increase in serious adverse events.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EAccording to Dr. Saver, the potential reasons for these neutral results may include the facts that magnesium passes across the blood-brain barrier slowly, which delays the impact on the central nervous system, and that magnesium alone may be insufficient to suppress the entire ischemic cascade in this environment.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EAlthough the study failed to meet its primary objective, the FAST-MAG trial resulted in the development of a new prehospital research network, which will allow researchers to test other promising neuroprotective therapies for acute stroke care in the future. This study also demonstrated that it is feasible to initiate potential neuroprotective treatment within the first 2 hours of stroke onset.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/6\/8.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp9ve\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}