RT Journal Article SR Electronic A1 Nierengarten, Mary Beth T1 Single-Dose Ketamine Associated with Rapid Improvement of Depressive Symptoms JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 8 SP 17 OP 18 DO 10.1177/155989771408009 UL http://mdc.sagepub.com/content/14/8/17.abstract AB Data from a randomized clinical trial show that patients with moderate to severe depressive symptoms treated with a single dose of ketamine show rapid improvement of depressive symptoms compared to patients treated with a psychoactive placebo control. This article discusses outcomes of the Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial [Murrough JA et al. Am J Psychiatry 2013].