RT Journal Article SR Electronic A1 Vinall, Maria T1 Evolving MS Treatment Strategies JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 29 SP 26 OP 29 DO 10.1177/155989771429020 UL http://mdc.sagepub.com/content/14/29/26.abstract AB The assessment of disease activity and burden has evolved from one based on clinical activity to one based on radiologic criteria (eg, number of new/enlarging T2 lesions, number of gadolinium-enhancing [Gd+] lesions, and brain atrophy/black holes). Treatment has moved from slowing disease progression to treatments (eg, natalizumab, fingolimod, interferon beta-1b [IFN-β-1b]) that improve and sustain function.