RT Journal Article SR Electronic A1 Parry, Nicola T1 Lowering the Influence of Exacerbations in COPD JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 11 SP 30 OP 33 DO 10.1177/155989771411020 UL http://mdc.sagepub.com/content/14/11/30.abstract AB This article discusses the significance of exacerbations and rehospitalizations in chronic obstructive pulmonary disease (COPD) in contributing to the high mortality rate associated with the disease. Recent data were also highlighted, showing that human rhinovirus (HRV) infection is common in frequent exacerbators, and how secondary bacterial infection may represent a mechanism for exacerbation recurrence and therefore a potential target for novel therapies.