RT Journal Article SR Electronic A1 Mosley, Mary T1 Antibiotic Resistance: Treatment and Drug Development Challenges Addressed JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 11 SP 28 OP 29 DO 10.1177/155989771411019 UL http://mdc.sagepub.com/content/14/11/28.abstract AB The resistance of infectious organisms to currently available antibiotics is a major medical challenge. The prevalence and mechanisms of multidrug-resistant pathogens vary widely worldwide. In the United States and Europe, the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) appears to have stabilized, while it is increasing in other regions [Dantes R et al. JAMA Intern Med 2013]. Antibiotic resistance to gram-negative bacteria continues to increase and represents one of the biggest challenges.