RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 IMPACT Study: Rhythm-Guided Anticoagulation Therapy Did Not Improve Outcomes
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 21
SP 14
OP 15
DO 10.1177/155989771421008
UL http://mdc.sagepub.com/content/14/21/14.abstract
AB Thromboembolism (TE) risk appears to be related to the burden of device-detected atrial tachyarrhythmias (AT) [Glotzer TV et al. Circ Arrhythm Electrophysiol 2009]. The investigators of the single-blinded Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke Risk Trial [IMPACT; NCT00559988] hypothesized that a home monitoring—guided oral anticoagulation strategy, including initiation early after AT detection and withdrawal after a prespecified window without AT, might reduce TE and hemorrhage in patients with an implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator device.