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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ECharacterized by neutrophilic inflammation of the scalp, folliculitis decalvans (FD) has an unknown etiology and results in painful, recurrent purulent follicular exudation. Azithromycin treatment in patients with FD resulted in a significant decrease in the number of papules and pustules on the scalp and improved the global subjective score, as discussed in this article.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHair Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHair Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EAzithromycin treatment in patients with folliculitis decalvans (FD) resulted in a significant decrease in the number of papules and pustules on the scalp and improved the global subjective score. Rui Oliveira-Soares, MD, CUF Descobertas Hospital, Lisbon, Portugal, presented data from a study that evaluated the effect of azithromycin monotherapy on FD.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ECharacterized by neutrophilic inflammation of the scalp, FD has an unknown etiology and results in painful, recurrent purulent follicular exudation. The typical treatment for FD includes systemic antimicrobial agents, such as tetracycline antibiotics. However, some tetracyclines may cause hyperpigmentation, particularly in response to sunlight; in contrast, azithromycin is less likely to cause hyperpigmentation and it has been successfully used to treat acne [Hasibur MR, Meraj Z. \u003Cem\u003EMymensingh Med J.\u003C\/em\u003E 2013; Antonio JR et al. \u003Cem\u003EJ Dermatolog Treat\u003C\/em\u003E. 2008; Innocenzi D et al. \u003Cem\u003EActa Dermatovenerol Croat\u003C\/em\u003E. 2008]. The purpose of this study was to evaluate the safety and efficacy of azithromycin for the treatment of FD.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn this single-arm study, 19 patients with a first diagnosis of FD were enrolled at least 6 months after discontinuing any prior medication. The study treatment was azithromycin monotherapy administered as 500 mg\/d for 3 consecutive days every 2 weeks for 6 months. All patients had persistent disease that was either stable or not responsive to prior therapy. The primary end point of the study was the change in the number of intact or crusted papules, or pustules present on the scalp. The secondary end point was change in a global subjective symptoms, including pain, burning sensation, and pruritus.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ETreatment with azithromycin resulted in a significant decrease in the number of papular and pustular lesions over 6 months compared with baseline (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001). In addition, the patient-reported symptoms decreased at 1 month and had not increased by 6 months.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EIn conclusion, Prof Oliveira-Soares stated that, in his opinion, the data from this study suggest that azithromycin treatment of FD resulted in a decrease in the number of papular and pustular lesions, as well as improvement in global subjective symptoms. As a result, Prof Oliveira-Soares suggested that azithromycin may be a reasonable alternative to tetracycline therapy, particularly during the summer months.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/37\/14.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzop9p\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}