PT  - JOURNAL ARTICLE
AU  - Nichols, Emma Hitt
ED  - Krueger, James
TI  - IL-23 Blockade with BI 655066 Improves PASI in Psoriasis
DP  - 2014 Dec 01
TA  - MD Conference Express
PG  - 12--13
VI  - 14
IP  - 37
4099  - http://mdc.sagepub.com/content/14/37/12.short
4100  - http://mdc.sagepub.com/content/14/37/12.full
AB  - Secretion of interleukin (IL)-23 by myeloid dendritic cells plays a role in the initiation of psoriasis. In addition, chronic psoriasis is maintained, at least in part, by the continued secretion of IL-23, which promotes the secretion of chemokines and antimicrobial peptides by keratinocytes, resulting in amplification that causes further IL-23 secretion. This article discusses the combination of IL-23 blockade with a single dose of the monoclonal antibody BI 655066 in the Single Rising Dose Study of BI 655066 in Patients With Moderate and Severe Psoriasis [NCT01577550].