RT Journal Article
SR Electronic
A1 Kuznar, Wayne
T1 Heterogeneity, Genome Complexity of TNBC Complicate Therapy
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 56
SP 23
OP 24
DO 10.1177/1559897715571080
UL http://mdc.sagepub.com/content/14/56/23.abstract
AB Triple-negative breast cancer is a heterogeneous disease and therefore presents treatment challenges, as targetable characteristic molecular abnormalities have not yet been identified. As with BRCA1-associated breast cancer, defective DNA repair and homologous recombination are implicated in sporadic TNBC, engendering sensitivity to platinum chemotherapy and poly (ADP-ribose) polymerase.