Summary
A single dose of inclacumab, a fully human recombinant monoclonal antibody directed against P-selectin, appears to reduce myocardial damage in patients undergoing percutaneous coronary intervention (PCI) as measured by biomarker concentration. Results from a randomized Phase 2 trial showed a reduction in levels of troponin I at 16 and 24 hours post PCI with a single dose of incalcumab 20 mg/kg when administered prior to PCI. The effect of a single dose of inclacumab on myocardial damage was examined in the Study of RO4905417 in Patients With Non ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention [SELECT-ACS; Tardif JC et al. J Am Coll Cardiol 2013].
- Interventional Techniques & Devices Myocardial Infarction
- Cardiology Clinical Trials
- Interventional Techniques & Devices
- Cardiology & Cardiovascular Medicine
- Myocardial Infarction
- Cardiology Clinical Trials
- © 2013 MD Conference Express®