RT Journal Article SR Electronic A1 Vinall, Phil T1 Update on Basal and Bolus Insulin Therapies JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 10 SP 22 OP 23 DO 10.1177/155989771210010 UL http://mdc.sagepub.com/content/12/10/22.abstract AB Insulin is released continuously by the pancreas at a nearly constant rate between meals and in the fasting state (basal insulin secretion). This article discusses the data on various basal insulins, as well as evolution of rapid-acting insulin, limitations of current insulin preparations, and pipeline products.