PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - Sadaka, Mohamed
TI  - FAME-Trials Family: Physiology, Decision-Making, and Clinical Outcomes
DP  - 2012 Dec 01
TA  - MD Conference Express
PG  - 8--9
VI  - 12
IP  - 8
4099  - http://mdc.sagepub.com/content/12/8/8.short
4100  - http://mdc.sagepub.com/content/12/8/8.full
AB  - This article discusses the use of fractional flow reserve (FFR) with angiography for detecting significant coronary artery stenosis. FFR is the only functional index that has been validated against a true gold standard. All studies performed in a wide range of clinical and angiographic conditions found an FFR threshold of 0.75 to 0.80 to detect significant stenosis, with a sensitivity of 90% and specificity of 100% [Pijls NHJ et al. N Engl J Med 1996].