RT Journal Article SR Electronic A1 Buckley, Rita A1 Rizzo, Toni T1 Benefit of PFO Closure in Cryptogenic Stroke Remains Elusive JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 17 SP 25 OP 27 DO 10.1177/155989771217013 UL http://mdc.sagepub.com/content/12/17/25.abstract AB Approximately 30% to 40% of ischemic strokes are classified as cryptogenic because a recognized cause is not identified [Sacco RL et al. Ann Neurol 1989]. Paradoxical embolism due to patent foramen ovale (PFO) is a possible cause of ischemic stroke, particularly in young cryptogenic stroke patients. Several presentations at TCT 2012 added important data to the growing literature about PFO closure and highlighted how elusive secondary stroke prevention with device therapy remains.