Summary

The Endovascular Valve Edge-to-edge Repair Study [EVEREST II; NCT00209274] compared the percutaneous implantation of a clip that grasps and approximates the edges of the mitral leaflets at the origin of the regurgitant jet with conventional surgery for mitral value repair. Percutaneous repair, however, is less effective at reducing mitral regurgitation than conventional surgery. However, the procedure was associated with better safety and improvements in other secondary outcomes, such as left ventricular dimensions and New York Heart Association class [Feldman T et al. N Engl J Med 2011].