Summary

Data from studies such as the Surgical Trial in Intracerebral Hemorrhage [STICH] and Factor Seven for Acute Hemorrhagic Stroke Treatment [FAST] trial have suggested that intraventricular hemorrhage (IVH) volume is a predictor of mortality. Preclinical data suggest that intraventricular thrombolysis leads to faster ventricular clearance and better recovery. The CLEAR- IVH trial sought to follow up on these ideas in a phase 2 study, and this article gives an overview of the results and plans for a phase 3 study.