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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EResearch on drug-eluting stents (DES) has yielded conflicting data about the safety and efficacy of DES in patients with myocardial infarction (MI). Analysis of data from a large registry of stents suggested that DES are not associated with inferior clinical outcomes. In fact, adjusted rates of death, revascularization, and reinfarction were lower among patients who received a DES than among patients who received a bare-metal stent.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Emyocardial infarction\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Einterventional techniques \u0026amp; devices clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EResearch on drug-eluting stents (DES) has yielded conflicting data about the safety and efficacy of DES in patients with myocardial infarction (MI). Analysis of data from a large registry of stents suggested that DES are not associated with inferior clinical outcomes. In fact, adjusted rates of death, revascularization, and reinfarction were lower among patients who received a DES than among patients who received a bare-metal stent (BMS).\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003ELaura Mauri, MD, MSC, Brigham and Women\u0027s Hospital, Boston, MA, reported on an observational study that involved the evaluation of patients who had a stent inserted for acute MI in the state of Massachusetts. Of the 7216 patients identified in the database, 4016 received a DES and 3200 received a BMS. Dr. Mauri explained that because there is a bias in selecting the type of stent for an individual patient, propensity score matching was done, and the patients in the 2 groups were matched on as many as 63 patient-, procedure-, and hospital-related variables. Data on 2629 patients in each group formed the basis of the analysis.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe researchers sought to determine if there was a signal of harm associated with DES in patients with acute MI. Dr. Mauri reported that the overall outcomes favored DES. Specifically, the 2-year, risk-adjusted mortality rate was significantly lower for patients with DES than for those with BMS (10.4% vs 13.2%; p=0.002). The rate of revascularization was also significantly lower in association with DES (15.5% vs 20.8%; p\u0026lt;0.001). The rate of reinfarction was lower, but the difference was not significant (9.5% vs 11%; p=0.08).\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003E\u201cThese findings are reassuring,\u201d Dr. Mauri said. \u201cAlthough neither bare-metal stents nor drug-eluting stents were originally approved in the setting of acute myocardial infarction, it is probably the most important condition that we treat with stents. This study confirms that the same benefits that DES offer other patients in preventing restenosis exist for patients with MI, and there doesn\u0027t appear to be any trade-off in increased risk of repeat MI or death.\u201d She added that patients with a DES must be able to take prolonged dual antiplatelet therapy with aspirin and a thienopyridine for one year.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EBecause patients with MI are at higher risk for late stent thrombosis than patients with stable angina, longer follow-up is needed to monitor the outcome over time. Dr. Mauri said that she and her colleagues plan to continue follow-up and re-examine the findings when more data are available.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/2\/11.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmg0p\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}