RT Journal Article
SR Electronic
A1 Vinall, Maria
T1 Effect of Previous Bisphosphonate Use on Response to Zoledronic Acid
JF MD Conference Express
YR 2008
FD SAGE Publications
VO 8
IS 5
SP 14
OP 14
DO 10.1177/155989770800800507
UL http://mdc.sagepub.com/content/8/5/14.1.abstract
AB The HORIZON Pivotal Fracture Trial [NCT00049829] showed that once-yearly zoledronic acid significantly reduces the risk of vertebral, hip, and other fractures [Black D et al. N Engl J Med 2007]. This article discusses the results of a planned subanalysis from HORIZON that evaluated the effect of prior bisphosphonate use on the primary endpoints of new vertebral fracture (in patients who were not taking concomitant osteoporosis medications) and non-vertebral fractures (in all patients).