RT Journal Article
SR Electronic
A1 Canavan, Neil
T1 Tamoxifen Metabolism, SSRIs, and the Cancer Patient
JF MD Conference Express
YR 2008
FD SAGE Publications
VO 8
IS 3
SP 26
OP 27
DO 10.1177/155989770800800319
UL http://mdc.sagepub.com/content/8/3/26.abstract
AB For patients with comorbid medical conditions, knowledge of drug metabolism is important and may in fact be critical in the oncology setting. A case in point is the widespread use of the anti-estrogen compound tamoxifen, which acts via estrogen receptor modulation. Unfortunately, one of the more common adverse events that occur with this drug is hot flashes, a condition that is uncomfortable to the point of discouraging long-term treatment adherence. An attempt to resolve this discomfort may result in additional unforeseen risk.