PT  - JOURNAL ARTICLE
AU  - Canavan, Neil
ED  - Flockhart, David
TI  - Tamoxifen Metabolism, SSRIs, and the Cancer Patient
DP  - 2008 Nov 01
TA  - MD Conference Express
PG  - 26--27
VI  - 8
IP  - 3
4099  - http://mdc.sagepub.com/content/8/3/26.short
4100  - http://mdc.sagepub.com/content/8/3/26.full
AB  - For patients with comorbid medical conditions, knowledge of drug metabolism is important and may in fact be critical in the oncology setting. A case in point is the widespread use of the anti-estrogen compound tamoxifen, which acts via estrogen receptor modulation. Unfortunately, one of the more common adverse events that occur with this drug is hot flashes, a condition that is uncomfortable to the point of discouraging long-term treatment adherence. An attempt to resolve this discomfort may result in additional unforeseen risk.