Summary

Florian Holsboer, director of the Max-Planck Institute for Psychiatry for 25 years, called for a reengineering of the drug development process for antidepressants, meaning a shift from a focus on blockbuster drugs capable of treating all depression to use of biomarkers to target subsets of patients based on disease etiology.

  • antidepressant
  • depression
  • monoaminergic
  • imipramine
  • CRH
  • vasopressin
  • ACTH
  • hypothalamus
  • pituitary
  • HPA axis
  • CRH receptor antagonist
  • psychiatry & psychology clinical trials
  • mood disorders
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