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{\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022highwire\u0022:{\u0022markup\u0022:[{\u0022requested\u0022:\u0022full-text\u0022,\u0022variant\u0022:\u0022full-text\u0022,\u0022view\u0022:\u0022full\u0022,\u0022pisa\u0022:\u0022spmdc;14\\\/2\\\/27\u0022},{\u0022requested\u0022:\u0022long\u0022,\u0022variant\u0022:\u0022full-text\u0022,\u0022view\u0022:\u0022full\u0022,\u0022pisa\u0022:\u0022spmdc;14\\\/2\\\/27\u0022}],\u0022ac\u0022:{\u0022spmdc;14\\\/2\\\/27\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022spmdc;14\\\/2\\\/27\u0022,\u0022atom_uri\u0022:\u0022\u0022,\u0022jcode\u0022:\u0022spmdc\u0022}}},\u0022googleanalytics\u0022:{\u0022trackOutbound\u0022:1,\u0022trackMailto\u0022:1,\u0022trackDownload\u0022:1,\u0022trackDownloadExtensions\u0022:\u00227z|aac|arc|arj|asf|asx|avi|bin|csv|doc(x|m)?|dot(x|m)?|exe|flv|gif|gz|gzip|hqx|jar|jpe?g|js|mp(2|3|4|e?g)|mov(ie)?|msi|msp|pdf|phps|png|ppt(x|m)?|pot(x|m)?|pps(x|m)?|ppam|sld(x|m)?|thmx|qtm?|ra(m|r)?|sea|sit|tar|tgz|torrent|txt|wav|wma|wmv|wpd|xls(x|m|b)?|xlt(x|m)|xlam|xml|z|zip\u0022,\u0022trackUrlFragments\u0022:1},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/libraries\\\/cluetip\\\/jquery.cluetip.js\u0022:1,\u0022sites\\\/all\\\/libraries\\\/cluetip\\\/lib\\\/jquery.hoverIntent.js\u0022:1,\u0022sites\\\/all\\\/libraries\\\/cluetip\\\/lib\\\/jquery.bgiframe.min.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/highwire_markup_process\\\/js\\\/highwire_at_symbol.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/highwire_markup_process\\\/js\\\/highwire_article_reference_popup.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/google_analytics\\\/googleanalytics.js\u0022:1,\u00220\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\n\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ERepair of shoulder injuries is rising and multiple treatment options exist. Multiple factors are involved in satisfactory healing of the rotator cuff including the quality of the tendon and muscle, repair biomechanics, and patient quality. This article discusses patch reinforcement in the repair of rotator cuffs, as well as about biologics that are available for rotator cuff repair, treating fractures with reverse arthroplasty, and indications for hemiarthroplasty and total shoulder replacement.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EShoulder \u0026amp; Elbow Conditions\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOrthopaedic Procedures\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOrthopaedics\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EShoulder \u0026amp; Elbow Conditions\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOrthopaedic Procedures\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ERepair of shoulder injuries is rising and multiple treatment options exist. T. Bradley Edwards, MD, Texas Orthopedic Hospital, Houston, Texas, USA, discussed patch reinforcement in the repair of rotator cuffs. Multiple factors are involved in satisfactory healing of the rotator cuff including the quality of the tendon and muscle, repair biomechanics, and patient quality. The use of a patch in rotator cuff repair may be beneficial to aid in healing when reinforcement with the suture line, augmentation of the repair, or interposition\/replacement of the tendon is needed.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ESuture line reinforcement with an absorbable patch (such as poly-4-hydroxybutyrate) may be indicated in a case where a poor-quality tendon is present, as sutures can pull through such a tendon. Although suture line reinforcement logically should have favorable outcomes, clinical data is currently not available.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EAugmentation of the repair with a patch may also be indicated in cases of poor tendon quality, particularly in the tendon opposed to the greater tuberosity. In this case, augmentation with a biologically engineered patch may improve the ability of the repaired tendon to handle a load. A Level I study demonstrated that the Restore patch caused an unacceptable level of postoperative inflammation [Iannotti JP et al. \u003Cem\u003EJ Bone Joint Surg Am\u003C\/em\u003E 2006], whereas several Level IV studies (without a control) demonstrated that human and porcine patches did not cause an inflammatory response [Malcarney HL et al. \u003Cem\u003EAm J Sports Med\u003C\/em\u003E 2005]. Several Level IV studies found that the GraftJacket also did not cause an inflammatory response. In addition, a Level II, prospective, controlled trial demonstrated that tendon augmentation with the GraftJacket resulted in better American Shoulder and Elbow Surgeons (ASES) score, and constant and healing rates on magnetic resonance imaging (MRI), although these scores did not achieve minimally clinically important differences [Barber FA et al. \u003Cem\u003EArthroscopy\u003C\/em\u003E 2012]. Dr. Edwards noted that the limited data from these trials highlight that there is still question of whether tendon augmentation is worth the added time and effort, in terms of outcomes.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EIn the case of massive rotator cuff tear, a biologically engineered patch can be used to essentially replace the absent tissue. Dr. Edwards highlighted that he uses this technique rarely and only in patients who have good-quality muscle with minimal fatty infiltration and no pseudoparalysis.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ELeesa M. Galatz, MD, Washington University School of Medicine, St. Louis, Missouri, USA, presented information about biologics that are available for rotator cuff repair. Platelet rich plasma (PRP) includes alpha granules that contain multiple growth factors, cytokines, and proteins involved in cell recruitment, proliferation, and angiogenesis, which are important to healing tissue.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EPRP is available as activated or nonactivated. Clotting results in activation of PRP, in which the alpha granules degranulate and release 100% of their factors within 1 hour. In contrast, nonactivated PRP is activated by exposure to collagen and my result in delayed release. Platelet rich fibrin matrix (PRFM) is a fibrin matrix which contain platelets within a more solid clot-like substance. The platelets are activated as the fibrin matrix is absorbed, resulting in a slower, more sustained release. Because cell metabolism, proliferation, and extracellular matrix production occur between 10 and 14 days following a tendon repair, use of activated PRP may not be ideal for rotator cuff repairs, as the factors are depleted during the timeframe in which they are most needed (ie, 10 to 14 days).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003ESeveral studies have been conducted to evaluate the effect of PRP on rotator cuff repair and demonstrated no improvement in clinical or structural outcomes [Weber SC et al. \u003Cem\u003EAm J Sports Med\u003C\/em\u003E 2013; Jo CH et al. \u003Cem\u003EAm J Sports Med\u003C\/em\u003E 2011; Catricini R et al. \u003Cem\u003EAm J Sports Med\u003C\/em\u003E 2010]. In addition, a Level II randomized trial of 79 patients demonstrated that the rate of healing was 67% in the arm that received PRFM compared with 81% in the control arm, which did not receive PRFM, suggesting that PRFM treatment may actually have a negative effect [Rodeo SA et al. \u003Cem\u003EAm J Sports Med\u003C\/em\u003E 2012].\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EAnother emerging biologic is mesenchymal stem cells, but there are few studies that evaluated the effect of mesenchymal stem cells in rotator cuff repair, and these studies have been mostly in animal models so far. In one study, stem cells alone had no effect on outcomes, but stem cells transfected to express MT1-MMP demonstrated improved insertion-site characteristics, and structural and material properties similar to that of healing tissue [Gulotta LV et al. \u003Cem\u003EAm J Sports Med\u003C\/em\u003E 2010]. Similarly, the few human studies that have been performed have demonstrated that stem cells alone are not beneficial. Stem cells transfected with the transcription factor scleraxis provided some benefit in another animal study [Gulotta LV Rodeo SA. \u003Cem\u003EClin Orthop Relat Res\u003C\/em\u003E 2011]. Only one published study documents the use of stem cells in a human. In this study, autologous bone marrow mononuclear cells (BMMC) were injected into the tendon borders during rotator cuff repair. Although there was no control group to compare the results with, the UCLA shoulder scale core increased from 12 to 31, and tendon integrity was maintained during the 12 months of follow-up. This study showed that use was safe, but it is difficult to make conclusions about efficacy due to the lack of a comparator group [Ellera Gomes JL et al. \u003Cem\u003EKnee Surg Sports Traumatol Arthrosc\u003C\/em\u003E 2012]. Dr. Galatz outlined the challenges that stem cells must overcome to be successful, such as needing to be present in large numbers, tissue adherence, angiogenesis, directing growth factors, inflammation, apoptosis, and differentiation.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EEdward V. Craig, MD, MPH, Hospital for Special Surgery, New York, New York, USA, discussed treating fractures with reverse arthroplasty. One treatment of shoulder fractures is osteosynthesis, but fracture displacement, screw problems, and avascular necrosis can occur. Another treatment option is hemiarthroplasty (HA), but problems with tuberosity resorption or pull-off and late glenoid wear can occur. In addition, it is difficult to revise a failed HA. As a result of these issues, reverse arthroplasty was developed as another treatment option. Although complications such as hematoma, notching, and implant failure can occur, the rates of these nonmajor complications are decreasing.\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EA recent systematic review of nine studies included patients with a mean age of 77 years and a constant score of 55.9 found that with a mean follow-up of 43 months, patients scored a mean of 122 for front flexion and 18 for external rotation, and the scores were better if the greater tuberosity healed [Anakwenze OA et al. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2014]. In addition, several clinical studies have compared HA with reverse arthroplasty (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E). In general, these studies found that outcomes improved or range of motion was achieved earlier with reverse arthroplasty compared with HA.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/15665\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/15665\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15665\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-12\u0022 class=\u0022first-child\u0022\u003EClinical Studies Comparing Hemiarthroplasty to Reverse Arthroplasty\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-14\u0022\u003EThomas Throckmorton, MD, Campbell Clinic, Germantown, Tennessee, USA, outlined the indications for HA and total shoulder replacement (TSR). The use of HA has been controversial over the past 10 years and evidence to date suggests that TSA is superior based on pain relief, function, range of motion, and rate of revision for osteoarthritis [Radnay CS et al. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2007; Bishop FY, Flatow EL. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2005; Bryant D et al. \u003Cem\u003EJ Bone Joint Surg Am\u003C\/em\u003E 2005; Collins DN et al. \u003Cem\u003EJ Bone Joint Surg Am\u003C\/em\u003E 2004]. Long-term studies indicate that the 20-year survival rate of the implant is greater, as well as better pain and function scores, for TSA versus hemiarthroplasty [Bryant D et al. \u003Cem\u003EJ Bone Joint Surg Am\u003C\/em\u003E 2005; Lo IK et al. \u003Cem\u003EJ Bone Joint Surg Am\u003C\/em\u003E 2005; Sperling JW et al. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2004]. In addition, a long-term study with 11 years of follow-up demonstrated that only 20% of patients reported excellent outcomes; in contrast, 31% reported moderate to severe pain and 20% had to undergo revision to TSR [Rispoli DM et al. \u003Cem\u003EJ Bone Joint Surg Am\u003C\/em\u003E 2006].\u003C\/p\u003E\u003Cp id=\u0022p-15\u0022\u003EResurfacing hemiarthroplasty theoretically preserves proximal humerus bone stock. Intermediate follow-up of resurfacing demonstrated similar results as stemmed arthroplasty with good pain relief and range of motion improvement [Levy O, Copeland SA. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2004]. However, little data are available for long-term follow-up. Dr. Throckmorton suggested that hemiarthroplasty is indicated in young or high-demand patients who have reasonable glenoid cartilage and\/or a functioning cuff, meaning they can achieve forward elevation of 90\u00b0 or better.\u003C\/p\u003E\u003Cp id=\u0022p-16\u0022\u003EReam and run modified HA has also demonstrated improvement in pain, range of motion, and function at up to 4 years of follow-up [Saltzman MD et al. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2011; Lynch JR et al. \u003Cem\u003EJ Bone Joint Surg Am\u003C\/em\u003E 2007]. However, interposition modified HA has shown up to a 70% failure rate by 2 years and has therefore largely been abandoned [Straus EJ et al. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2013]. Similarly, although lateral meniscus allograft initially showed favorable results, mid-term studies are now demonstrating that the failure rate is 45% at \u0026lt;5 years. Dr. Throckmorton suggested that modified HA may be indicated in young or high-demand patients with glenohumeral arthritis.\u003C\/p\u003E\u003Cp id=\u0022p-17\u0022\u003EIndications for TSA include symptomatic glenohumeral arthritis with an intact rotator cuff, and TSA is considered the gold-standard treatment for osteoarthritis. Dr. Throckmorton stated that young to elderly and low-to-medium demand patients with an intact or reparable rotator cuff are candidates for TSA. Long-term studies dating from 1975 to 1981 with up to 17 years of follow-up demonstrated that 83% of patients had long-term pain relief and component retention was present in 87% at 15 years. Another long-term study demonstrated that the 20-year survival of the implant was 85% and the revision rate was only 7% [Deshmukh AV et al. \u003Cem\u003EJ Shoulder Elbow Surg\u003C\/em\u003E 2005].\u003C\/p\u003E\u003Cp id=\u0022p-18\u0022\u003EDepending on the shoulder injury, multiple surgical treatment options that range from using a biologically engineered patch, to biologics, to prosthesis use are available. Although controversies exist as to which method is superior, clinical data are accumulating that can serve as a guide for surgeons who treat shoulder injuries.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/2\/27.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzpd43\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzpd43\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}