RT Journal Article
SR Electronic
A1 Hoyle, Brian
T1 Perioperative Clonidine Does Not Reduce CV Events in Patients Having Noncardiac Surgery (POISE-2)
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 4
SP 22
OP 23
DO 10.1177/155989771404012
UL http://mdc.sagepub.com/content/14/4/22.abstract
AB Clonidine, a centrally acting a-agonist, does not reduce the risk of perioperative myocardial infarction or death in noncardiac surgery; however, it did cause clinically significant bradycardia and hypotension. The findings of the Perioperative Ischemic Evaluation-2 Trial [POISE-2; Devereaux PJ et al. N Engl J Med 2014] are discussed in this article.