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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EMultiple causes of encephalitis exist, including infectious and autoimmune agents. This article discusses the pathophysiology of acute encephalitis related to several more common forms of the disease.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurological Autoimmune Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EViral Infections\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBacterial Infections\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInflammatory Diseases\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurological Autoimmune Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EViral Infections\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EBacterial Infections\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInflammatory Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EMultiple causes of encephalitis exist, including infectious and autoimmune agents. Christina M. Marra, MD, University of Washington, Seattle, Washington, USA, discussed the pathophysiology of acute encephalitis related to several more common forms of the disease.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EInfectious encephalitis is typically caused by a virus, although there are more than 100 etiologies of encephalitis currently identified (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E). In other cases of encephalitis, the etiology can be antibody mediated, such as when antibodies target the N-methyl-D-aspartate receptor (NMDAR) or a voltage-gated potassium channel (VGKC) complex protein, leucine-rich, glioma inactivated 1 (LGI1). Encephalitis causes altered mental status, which can be mild or subtle in nature, and may mimic psychiatric disease. The cerebrospinal fluid (CSF) in encephalitis typically demonstrates a mildly elevated opening pressure, mild to moderate pleocytosis, protein levels of 50 to 100 mg\/dL, and normal glucose levels.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/15927\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/15927\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15927\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-4\u0022 class=\u0022first-child\u0022\u003ECommon Etiologies of Encephalitis\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-6\u0022\u003EGiven that there are multiple potential etiologies for encephalitis, it is important to look for clues that may indicate the correct etiology. For example, cases that develop in the late summer or early fall may be a result of a tickborne or mosquitoborne agent, whereas travel to particular geographic regions may provide a clue, such as infection with the Japanese encephalitis virus after travel to Asia. Other clues include underlying comorbidities, such as HIV, organ transplant, or immunosuppression therapy, all of which can increase susceptibility to infection and encephalitis by particular infectious agents.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EA common noninfectious type of encephalitis is anti-NMDAR encephalitis, which may be the most common cause of encephalitis in patients younger than 30 years of age [Gable MS et al. \u003Cem\u003EClin Infect Dis\u003C\/em\u003E 2012]. Common characteristics of patients with anti-NMDAR encephalitis include female sex and early and prominent psychiatric symptoms [Titulaer MJ et al. \u003Cem\u003ELancet Neurol\u003C\/em\u003E 2013]. Serum and CSF antibodies to the \u003Cem\u003EN-\u003C\/em\u003Eterminus of the NR1 subunit of the NMDAR and CSF characteristics can diagnose anti-NMDAR encephalitis [Gresa-Arribas N et al. \u003Cem\u003ELancet Neurol\u003C\/em\u003E 2014]. In addition, nonspecific abnormalities on magnetic resonance imaging, slowing and electrographic seizures on electroencephalography, and identification of a teratoma by pelvic or transvaginal ultrasound may be present. Initial treatment includes the administration of corticosteroids or IV ig with or without cyclophosphamide, as well as removal of the teratoma if present. For patients who do not respond to initial therapy, treatment with rituximab may lead to improvement. Although the majority of patients recover or have mild sequelae following anti-NMDAR encephalitis, 4% die from the disease, 20% remain severely disabled, and up to 25% will experience relapse.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThe most common sporadic cause of encephalitis is herpes simplex virus (HSV), primarily HSV-1, which can occur at any time of the year. It affects a bimodal age distribution, with the greatest number of patients being older than 40 years of age and younger than 20 years of age. Common symptoms include fever, headache, change in consciousness, dysphasia, personality changes, and seizures. Patients with HSV-associated encephalitis are typically treated with acyclovir for up to 21 days, or until polymerase chain reaction tests of CSF are negative for HSV. Treatment is important, as untreated patients have a mortality rate of 70% whereas treatment reduces the rate to 28%. In addition, as many as 50% of patients will experience neurologic or neuropsychiatric sequelae following HSV encephalitis.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EAnother type of encephalitis is caused by the intracellular parasite \u003Cem\u003EToxoplasmosis gondii\u003C\/em\u003E, which is contracted by ingestion of oocysts that are present in cat feces or cysts present in undercooked meat. It is estimated that 12% to 50% of the US population is seropositive for \u003Cem\u003ET gondii\u003C\/em\u003E. Encephalitis can develop in patients who experience reactivation of a latent infection, and presents as one or more brain abscesses. Common symptoms include headache, confusion, fever, altered mental status, seizures, hemiparesis, slowness, and cranial nerve palsies [Porter SB, Sande MA. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 1992]. Other characteristics that may help lead to the diagnosis of \u003Cem\u003EToxoplasma\u003C\/em\u003E encephalitis is more than one enhancing lesion on MRI, detectable serum anti-\u003Cem\u003EToxoplasma\u003C\/em\u003E IgG, exclusion of other diagnoses, and improvement of symptoms and neuroimaging abnormalities with a 10-day trial of therapy. Typical treatment includes primary therapy with pyrimethamine plus sulfadiazine or clindamycin plus folinic acid followed by maintenance therapy with the same agents at reduced doses.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EAlthough rare, encephalitis can result in high morbidity and mortality, even after treatment. There are multiple potential etiologies associated with encephalitis, which pose a challenge when determining a differential diagnosis.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/6\/32\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022The editors would like to thank the many members of the 2014 American Academy of Neurology presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1279391335\u0022 data-figure-caption=\u0022The editors would like to thank the many members of the 2014 American Academy of Neurology presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/6\/32\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/6\/32\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/6\/32\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15925\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\n            \u003Cp id=\u0022p-11\u0022 class=\u0022first-child\u0022\u003EThe editors would like to thank the many members of the 2014 American Academy of Neurology presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/6\/32.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzpakd\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzpakd\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzpakd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}