RT Journal Article SR Electronic A1 Rizzo, Toni T1 Controversies in Multiple Sclerosis Therapy JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 6 SP 18 OP 20 DO 10.1177/155989771406011 UL http://mdc.sagepub.com/content/14/6/18.abstract AB Considerable progress has been made in multiple sclerosis (MS) therapy in the 20 years since the first successful trial. Although several agents are now available for treating patients with MS, many issues remain regarding treatment of individual patients. This article discusses initiating MS therapy, and addressed the issues of switching and escalating therapy and of discontinuing therapy.