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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ETreatment with alemtuzumab is associated with durable improvements in magnetic resonance imaging (MRI) disease activity in patients with active relapsing-remitting multiple sclerosis. This article presents the 3-year results from An Extension Protocol for Multiple Sclerosis Patients Who Participated in Genzyme-Sponsored Studies of Alemtuzumab (\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00930553\u0026amp;atom=%2Fspmdc%2F14%2F6%2F9.1.atom\u0022\u003ENCT00930553\u003C\/a\u003E), an ongoing extension study of the Comparison of Alemtuzumab and Rebif\u00ae Efficacy in Multiple Sclerosis (CARE-MS) series of studies.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ETreatment with alemtuzumab is associated with durable improvements in magnetic resonance imaging (MRI) disease activity in patients with active relapsing-remitting multiple sclerosis, according to Douglas L. Arnold, MD, NeuroRX Research and Montreal Neurological Institute, McGill University, Montreal, Qu\u00e9bec, Canada, who presented the 3-year results from An Extension Protocol for Multiple Sclerosis Patients Who Participated in Genzyme-Sponsored Studies of Alemtuzumab (\u003Ca href=\u0022http:\/\/ClinicalTrials.gov\u0022\u003EClinicalTrials.gov\u003C\/a\u003E identifier: \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00930553\u0026amp;atom=%2Fspmdc%2F14%2F6%2F9.1.atom\u0022\u003ENCT00930553\u003C\/a\u003E), an ongoing extension study of the Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis (CARE-MS) series of studies. The results showed that participants were free of gadolinium-enhancing, new or enlarging T\u003Csub\u003E2\u003C\/sub\u003E and new T lesions after 3 years of follow-up. Alemtuzumab also slowed the yearly rate of brain volume loss.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn 2 previous Phase 3 head-to-head trials with patients with active relapsing-remitting multiple sclerosis (CARE-MS I in treatment-naive patients and CARE-MS II in those who relapsed on prior therapy), 2 annual courses of alemtuzumab 12 mg proved superior to subcutaneous interferon-b1a (44 mg 3 times\/wk) with respect to clinical efficacy and the reduction in MRI activity and brain volume loss over 2 years.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPatients treated with alemtuzumab in either of the CARE-MS studies continued uninterrupted follow-up in an extension study and were eligible for alemtuzumab retreatment (12 mg administered on 3 consecutive days \u003Csup\u003E3\u003C\/sup\u003E12 months after their previous courses of therapy) on evidence of disease activity. MRI was performed at study entry and annually for each patient, and studies were centrally analyzed by experts masked to treatment group assignment. All patients underwent T\u003Csub\u003E1\u003C\/sub\u003E-weighted pre- and post-Gd contrast, T\u003Csub\u003E2\u003C\/sub\u003E-weighted and proton density precontrast, fluid-attenuated inversion recovery precontrast, and 3-dimensional gradient-echo postcontrast MRI sequences before the administration of methylprednisolone. Brain atrophy was measured by brain parenchymal fraction.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EA total of 742 subjects entered the extension study (349 subjects from CARE-MS I and 393 from CARE-MS II). Durable effects on relapse rate and disability were reported at end of Year 1 of the extension study despite patients having been treated for only 2 years [Fox EJ et al. \u003Cem\u003ENeurology\u003C\/em\u003E 2013].\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe current report presents the results after 3 years of follow-up. In Year 3, 18% and 20% of the subjects in CARE-MS I and II, respectively, received retreatment with alemtuzumab; \u0026lt;3% of patients were treated with other disease-modifying therapies. The majority of alemtuzumab-treated patients were free of MRI activity (absence of both Gd-enhancing and new or enlarging T\u003Csub\u003E2\u003C\/sub\u003E hyperintense lesions) at both Year 2 and Year 3.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EDuring the same period, alemtuzumab also slowed brain volume loss as measured by brain parenchymal fraction. The median yearly rate of brain atrophy decreased over time (Year 0 to 1, \u22120.59% and \u22120.48% for CARE-MS I and II, respectively; Year 1 to 2, \u22120.25% and \u22120.22%; Year 2 to 3, \u22120.19% and \u22120.10%).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThese results support the efficacy of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis in both treatment-naive and previously treated patients and provide evidence of durability of benefit.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/6\/9.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzpa21\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}