RT Journal Article SR Electronic A1 Hoyle, Brian T1 Update on Treatment of Depression JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 8 SP 33 OP 34 DO 10.1177/155989771408019 UL http://mdc.sagepub.com/content/14/8/33.abstract AB This article discusses the search for rapidly acting antidepressant treatments for major depressive disorder, as well as the role of ketamine for treatment-resistant depression (TRD), an overview of glutamatergic drug targets in TRD, and novel devices to treat depression.