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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article presents results from the first half of the randomized controlled International Study to Predict Optimized Treatment in Depression [iSPOT-D; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00693849\u0026amp;atom=%2Fspmdc%2F14%2F8%2F16.2.atom\u0022\u003ENCT00693849\u003C\/a\u003E]. The study demonstrated that, for patients with major depressive disorder, escitalopram, sertraline, and venlafaxine extended release produced similar treatment response rates, with mild and similar side effects.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EMood Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPsychopharmacology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPsychiatry Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EPsychiatry\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMood Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPsychopharmacology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPsychiatry Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ERadu V. Saveanu, MD, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA, presented results from the first half of the randomized controlled International Study to Predict Optimized Treatment in Depression [iSPOT-D; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00693849\u0026amp;atom=%2Fspmdc%2F14%2F8%2F16.2.atom\u0022\u003ENCT00693849\u003C\/a\u003E]. The study demonstrated that, for patients with major depressive disorder (MDD), escitalopram, sertraline, and venlafaxine extended release (XR) produced similar treatment response rates, with mild and similar side effects.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EAlthough antidepressant medications (ADMs) are effective, their benefit could be enhanced by identifying pretreatment clinical or neurobiological features that predict response versus nonresponse to treatment, as well as features or moderators that help identify which specific treatment is the best match for a particular patient.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EWith this in mind, Dr. Saveanu and colleagues conducted the multiphase, multisite, randomized controlled iSPOT-D trial. This ongoing real-world effectiveness trial, with no placebo arm, was designed to identify genetic, physical, and psychological markers that predict specific response to a range of ADMs in a large group of outpatients diagnosed with MDD. Focusing on outcomes that may affect how personalized medicine is implemented in depression, the study was designed to identify predictors and moderators of outcomes in order to change how ADMs are selected.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ETo be included in the study, participants were required to be 18 to 65 years old, meet the DSM criteria for MDD, and score \u226516 on the Hamilton Rating Scale for Depression, 17-Item (HAM-D-17).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EExclusion criteria included suicidal ideation or planning, contraindication to study ADMs, recurrent or current substance dependence, and other mental disorders.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EOutcome measures were obtained 8 weeks after ADM treatment. The study\u0027s primary outcome was rate of treatment response (defined by \u226550% improvement) and remission (defined by score \u22647) using the clinician-rated HAM-D-17 score. Secondary outcomes included rate of treatment response (defined by \u226550% improvement) and remission (defined by score \u22645) using the self-reported Quick Inventory of Depressive Symptomatology, 16-Item (QIDS-SR16) score; functional capacity; and side effect burden to the three ADMs.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EIn Phase 1 of the trial, participants (n=1008; mean age 37.8 years; 57% female) were randomly assigned to receive escitalopram (10 mg\/day; maximum 20 mg\/day), sertraline (50 mg\/day; maximum 200 mg\/day), or venlafaxine XR (75 mg\/day; maximum 225 mg\/day), the three first-line ADMs prescribed worldwide.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EHAM-D-17 response rates were similar and consistent across the escitalopram, sertraline, and venlafaxine arms (61% vs 66% vs 60%, respectively; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E), as were HAM-D-17 remission rates (48% vs 46% vs 42%, respectively). QIDS-SR16 response rates (55.7% vs 55.6% vs 48.4%) and remission rates (41.0% vs 38% vs 33.8%, respectively) were also similar across the three arms. Side effects were also mostly mild, and they occurred in a similar number of participants among the three groups (85% vs 80% vs 79%, respectively).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/8\/16.2\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022HAM-D-17 Response Rates Across the Three ADM Arms (defined by \u0026#x2265; 50% improvement)\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-202434475\u0022 data-figure-caption=\u0022HAM-D-17 Response Rates Across the Three ADM Arms (defined by \u0026#x2265; 50% improvement)\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/8\/16.2\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/8\/16.2\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/8\/16.2\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15842\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-10\u0022 class=\u0022first-child\u0022\u003EHAM-D-17 Response Rates Across the Three ADM Arms (defined by \u2265 50% improvement)\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EHAM-D-17=Hamilton Rating Scale for Depression, 17-Item; XR=extended release.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003EReproduced with permission from RV Saveanu, MD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-11\u0022\u003EThe results of the first half of this study indicate that escitalopram, venlafaxine, and sertraline produce similar and consistent response rates in patients with MDD, with similar and mild side effects. These findings even the clinical research playing field for identifying predictors and moderators of response that can be translated into patient care, Dr. Saveanu concluded.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/8\/16.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzp8e2\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp8e2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}