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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003En analysis of genetic determinants of multiple sclerosis (MS) in African Americans has implicated the locus for non-sense-mediated mRNA decay factor 7 (SMG7), located on chromosome 1, as a potentially unique MS-associated site in this population.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Guidelines\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Guidelines\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EAn analysis of genetic determinants of multiple sclerosis (MS) in African Americans has implicated the locus for non-sense-mediated mRNA decay factor 7 (\u003Cem\u003ESMG7\u003C\/em\u003E), located on chromosome 1, as a potentially unique MS-associated site in this population. The results were reported by Noriko Isobe, MD, PhD, University of California at San Francisco, San Francisco, California, USA.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EWhile the prevalence of MS in people of African origin was once thought to be relatively low, this may not be the case. In African Americans, not only is the prevalence of MS higher than anticipated, it appears to be on the rise [Langer-Gould A et al. \u003Cem\u003ENeurology\u003C\/em\u003E. 2013; Wallin MT et al. \u003Cem\u003EBrain\u003C\/em\u003E. 2012]. The MS that develops in African Americans has been described as more severe than that in Europeans [Cree BAC et al. \u003Cem\u003ENeurology\u003C\/em\u003E. 2004], with \u003Cem\u003EHLA-DRB1*15:01\u003C\/em\u003E and \u003Cem\u003EHLA-DRB1*15:03\u003C\/em\u003E being especially associated with MS in African Americans [Isobe N et al. \u003Cem\u003ENeurology\u003C\/em\u003E. 2013; Oksenberg et al. \u003Cem\u003EAm J Hum Genet\u003C\/em\u003E. 2004].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe use of the ImmunoChip technology, in which different single nucleotide polymorphisms (SNPs) and small regions harboring genetic insertions or deletions are spaced out on a support that is used to probe entire genomes for the targets, has identified nearly 197 000 SNPs linked to a variety of diseases including type 1 diabetes, psoriasis, autoimmune thyroid disease, ankylosing spondylitis, ulcerative colitis, celiac disease, Crohn\u0027s disease, rheumatoid arthritis, MS, and others. Of these SNPs, 110 have been associated with MS in Europeans, with a further 48 identified as novel MS loci [IMSGC. \u003Cem\u003ENat Genet\u003C\/em\u003E. 2013].\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe present study assessed whether the MS-associated loci identified in Europeans were also identified in African Americans, and if there were other, unique loci in this population. Chromosome samples from 843 African Americans with confirmed MS were examined along with samples from 1612 subjects without any symptoms of MS. Twenty one of 96 European MS loci were properly matched with the particular SNP, indicating the accuracy of the approach. A standard ImmunoChip analysis identified 110 MS-associated SNPs that were not present in Europeans. Of these, 8 were located in linkage disequilibrium regions (r\u003Csup\u003E2\u003C\/sup\u003E \u0026gt; 0.5) of the original MS-associated SNPs. Of the 8, 7 were determined to lie outside of known MS-associated SNPs (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001). Finally, of the 7, \u003Cem\u003ESMG7\u003C\/em\u003E, located on chromosome 1, was implicated as being associated with MS in African Americans.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe rs2702180 SNP involved with \u003Cem\u003ESMG7\u003C\/em\u003E has been linked to the expression of \u003Cem\u003ESMG7\u003C\/em\u003E in brain tissue and lymphoblastoid cells [Gibbs JR et al. \u003Cem\u003EPLoS Genet\u003C\/em\u003E. 2010; Stranger BE et al. \u003Cem\u003ENat Genet\u003C\/em\u003E. 2007]. \u003Cem\u003ESMG7\u003C\/em\u003E abuts \u003Cem\u003ENCF2\u003C\/em\u003E, a gene that has been linked with systemic lupus erythematosus [Cunninghame Graham DS et al. \u003Cem\u003EPLoS Genet\u003C\/em\u003E. 2011].\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe researchers concluded that the \u003Cem\u003ESMG7\u003C\/em\u003E locus located on chromosome 1 is a potential candidate site in African Americans with MS. Next, since the ImmunoChip focuses on SNPs and not functional variants, studies involving more samples and functional analyses are needed to conclusively assess this potential association.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/29\/18.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp7se\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}