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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EProlonged release (PR)-fampridine treatment resulted in sustained and clinically meaningful improvement in walking ability and balance throughout a 6-month treatment period in individuals with multiple sclerosis (MS). The Exploratory Study to Assess the Effect of Fampridine (BIIB041) on Walking Ability and Balance in Participants With Multiple Sclerosis study [MOBILE; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01597297\u0026amp;atom=%2Fspmdc%2F14%2F29%2F17.1.atom\u0022\u003ENCT01597297\u003C\/a\u003E; Hupperts R et al. ACTRIMS\/ECTRIMS 2014 (poster P922)] evaluated the effect of PR-fampridine on walking ability, dynamic and static balance, and subjective impressions of well-being.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EProlonged release (PR)-fampridine treatment resulted in sustained and clinically meaningful improvement in walking ability and balance throughout a 6-month treatment period in individuals with multiple sclerosis (MS). The Exploratory Study to Assess the Effect of Fampridine (BIIB041) on Walking Ability and Balance in Participants With Multiple Sclerosis study [MOBILE; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01597297\u0026amp;atom=%2Fspmdc%2F14%2F29%2F17.1.atom\u0022\u003ENCT01597297\u003C\/a\u003E; Hupperts R et al. ACTRIMS\/ECTRIMS 2014 (poster P922)] evaluated the effect of PR-fampridine on walking ability, dynamic and static balance, and subjective impressions of well-being. Raymond Hupperts, MD, Orbis Medical Center, Sittard-Geleen, the Netherlands, presented the findings in a poster session.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EMaintaining mobility is among the greatest concerns for patients with MS [Sutliff MH. \u003Cem\u003ECurr Med Res Opin\u003C\/em\u003E. 2010]. PR-fampridine was approved to improve walking in MS based on the results of 2 pivotal trials [Goodman AD et al. \u003Cem\u003EAnn Neurol\u003C\/em\u003E. 2010; Goodman AD et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2009] that demonstrated consistent improvements on the Timed 25-Foot Walk (T25FW). The T25FW, however, may not fully assess all of the domains that control walking ability, including balance [Nogueira LA et al. \u003Cem\u003EMult Scler Int.\u003C\/em\u003E 2013].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EMOBILE was a randomized, double-blind, multicenter, placebo-controlled, exploratory 24-week phase 2 study conducted at 24 sites in 6 countries. Patients (n = 132) aged 18 to 70 years, with progressive and relapsing MS and an Expanded Disability Status Scale (EDSS) score of 4.0 to 7.0, were randomly assigned (1:1) to PR-fampridine 10 mg BID (n = 68) or placebo (n = 64) for 24 weeks. Outcome measures included walking ability assessment using the 12-item Multiple Sclerosis Walking Scale (MSWS-12) and Patient Global Impression of Change (PGIC); mobility and balance assessment using the Timed Up and Go (TUG) test and Berg Balance Scale (BBS); and subjective impression of well-being assessment using the Multiple Sclerosis Impact Scale (MSIS-29), physical subscale (PHYS), and EuroQoL-5 Dimension 5-level instrument (EQ-5D-5L). Safety and tolerability were assessed by monitoring adverse events (AEs).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EMean age of the patients was 49.8 years; 54% were women. The mean EDSS score was 5.7. Baseline to week 24 improvements in the MSWS-12, TUG test, BBS, and MSIS-29 PHYS were greater following treatment with PR-fampridine compared with placebo. Benefits declined by the week 26 visit following discontinuation of treatment at week 24.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EMore patients treated with PR-fampridine vs placebo reported improvement on the PGIC at the week 2 visit: 31 patients (46%) for PR-fampridine vs 16 (26%) for placebo. No apparent differences between treatment groups were observed in the EQ-5D-5L utility index. The cumulative percentage of patients with a mean improvement in the MSWS-12 score and TUG test was greater in the PR-fampridine-treated patients compared with the placebo group.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003ESafety findings were consistent with the known safety profile of PR-fampridine. The number of patients who discontinued (PR-fampridine, n = 13; placebo, n = 12) was similar. AEs were the main reason for discontinuation in both groups (PR-fampridine, n = 7; placebo, n = 5). No seizures were reported, and serious AEs were reported by fewer patients treated with PR-fampridine (2\/68; 3%) compared with placebo (5\/64; 8%). The common AEs were nasopharyngitis and urinary tract infection.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EIn this study, PR-fampridine improved a broad range of objective and patient-reported measures of walking ability. An ongoing phase 3 study will seek to confirm these findings.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/29\/17.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp7k1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}