PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - Arnold, Douglas L.
TI  - ADVANCE Trial: PEG-IFN-β-1a Every 2 Weeks Significantly Improved Outcomes over 2 Years in RRMS
DP  - 2014 Jul 01
TA  - MD Conference Express
PG  - 8--8
VI  - 14
IP  - 29
4099  - http://mdc.sagepub.com/content/14/29/8.short
4100  - http://mdc.sagepub.com/content/14/29/8.full
AB  - The 1-year results of the Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis [ADVANCE; Calabresi PA et al. Lancet Neurol. 2014] demonstrated superior clinical and magnetic resonance imaging (MRI) outcomes as compared with placebo in patients with relapsing-remitting multiple sclerosis (RRMS). Post hoc analyses showed that significantly more patients treated with peginterferon beta-1a (PEG-IFN-β-1a) versus placebo had no evidence of disease activity (NEDA) at year 1 [Calabresi PA et al. ACTRIMS/ECTRIMS. 2013 (poster P514)]. The aim of this analysis of the ADVANCE trial was to evaluate MRI outcomes and NEDA over 2 years.