Summary

This article presents results from the Phase 2 Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation trial [HARMONY; NCT01522651]. This randomized, double-blind, placebo-controlled trial demonstrated that a combination of ranolazine and low-dose dronedarone reduced the burden of paroxysmal atrial fibrillation when compared with either drug alone.