PT  - JOURNAL ARTICLE
AU  - Nichols, Emma Hitt
ED  - Packer, Milton
TI  - PARADIGM-HF: Rationale and Design
DP  - 2014 Aug 01
TA  - MD Conference Express
PG  - 11--12
VI  - 14
IP  - 12
4099  - http://mdc.sagepub.com/content/14/12/11.short
4100  - http://mdc.sagepub.com/content/14/12/11.full
AB  - The Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure and Reduced Ejection Fraction [PARADIGM-HF; NCT01035255] is the largest trial ever conducted with patients with heart failure with a reduced left ventricular ejection fraction and was designed to replace the current standard of care. This article discusses the rationale and design of the PARADIGM-HF trial.