PT - JOURNAL ARTICLE AU - Nichols, Emma Hitt ED - Trojanowski, John TI - Understanding Parkinson's Pathology is Key to Early Detection and Treatment DP - 2014 Aug 01 TA - MD Conference Express PG - 25--26 VI - 14 IP - 15 4099 - http://mdc.sagepub.com/content/14/15/25.short 4100 - http://mdc.sagepub.com/content/14/15/25.full AB - Understanding the underlying pathology of Parkinson's disease (PD) is critical in identifying the disease early and developing novel treatments. This article discusses the role of a-synuclein in PD, the extranigral pathology and preclinical detection of PD, as well as how the updated understanding of PD pathology explains its clinical phenotype