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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EExercise increases neuron proliferation in animal studies and improves motor function in patients with early-stage Parkinson\u0027s disease (PD). Multiple studies have demonstrated that the LSVT BIG\u00ae physical therapy exercise program is effective for improving the motor symptoms of PD. LSVT BIG is a program developed by LSVT Global that uses physical and occupational therapy in an intensive, whole-body, amplitude-based training protocol to treat individuals with PD. This article presents the results of a pilot study comparing the effects of the LSVT BIG program with those of a one-on-one exercise program in patients with PD.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EExtrapyramidal \u0026amp; Movement Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENursing Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EExtrapyramidal \u0026amp; Movement Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENursing\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EExercise increases neuron proliferation in animal studies and improves motor function in patients with early-stage Parkinson\u0027s disease (PD). Multiple studies have demonstrated that the LSVT BIGR physical therapy exercise program is effective for improving the motor symptoms of PD. LSVT BIG is a program developed by LSVT Global that uses physical and occupational therapy in an intensive, whole-body, amplitude-based training protocol to treat individuals with PD. Khashayar Dashtipour, MD, PhD, Loma Linda University School of Medicine, Loma Linda, California, USA, presented the results of a pilot study comparing the effects of the LSVT BIG program with those of a one-on-one exercise program in patients with PD.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ENine patients with early- to middle-stage PD were randomly assigned to the LSVT BIG physical therapy exercise program (n=4) versus a one-on-one exercise program consisting of treadmill plus seated trunk and limb exercise (n=5). Both exercise programs took place in 16 1-hour supervised sessions. The goal was to compare the effects of each program on motor as well as on nonmotor symptoms in these patients with PD. The patients were assessed before and after the exercise intervention with the Unified Parkinson\u0027s Disease Rating Scale (UPDRS), UPDRS motor (UPDRS M), Beck Depression Inventory (BDI), Beck Anxiety Inventory, and Modified Fatigue Impact Scale (MFIS). The assessments were given at baseline (first evaluation) and monthly at 3 follow-up visits (second, third, and fourth evaluations). Follow-up data were compared with baseline data using Wilcoxon rank sum testing. The analysis was repeated separately for each of the assessments and for each evaluation period.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn the combined cohort of all 9 patients, all assessment results were improved from baseline at the follow-up evaluations, with statistically significant decreases in the UPDRS score at the second (p=0.0237), third (p=0.0361), and fourth (p=0.0142) evaluations. UPDRS M scores were significantly decreased from baseline at the third (p=0.0208) and fourth (p=0.0313) evaluations. BDI scores were significantly decreased at the second (p=0.0014), third (p\u0026lt;0.0001), and fourth (p\u0026lt;0.0001) evaluations. MFIS scores were significantly decreased only at the fourth evaluation (p=0.0022).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThere were no significant differences between the LSVT BIG physical therapy and one-on-one exercise groups at any of the evaluations except for the MFIS score, which was significantly decreased from baseline to the fourth evaluation (\u201311.2 vs 0.0, p=0.0159) in the one-on-one exercise group compared with the LSVT BIG group. Changes from baseline to the fourth evaluation for the other assessments in the one-on-one exercise group compared with the LSVT BIG group are shown in \u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/14551\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/14551\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14551\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EChange From Baseline to Fourth Evaluation, Both Groups\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-8\u0022\u003EThe results of this pilot study demonstrated a positive effect of exercise and physical therapy on motor and nonmotor symptoms in patients with PD, with reductions in all scores from baseline. The only significant difference between the 2 groups was the significantly reduced MFIS score at the final evaluation in the one-on-one exercise group compared with the LSVT BIG group. The results of this pilot study suggest that one-on-one exercise could be at least as effective as the LSVT BIG physical therapy program for improving the symptoms of PD, but larger trials are needed to validate these data.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/15\/15.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp4be\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzp4be\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}