RT Journal Article
SR Electronic
A1 Lederman, Lynne
T1 Forced Vital Capacity is Inadequate for Assessing ILD in SSc
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 17
SP 21
OP 22
DO 10.1177/155989771417013
UL http://mdc.sagepub.com/content/14/17/21.abstract
AB Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) frequently results in ventilatory restriction, a major cause of death in these individuals. Clinical trials in patients with SSc-related ILD have traditionally used forced vital capacity percentage (FVC%) predicted as a primary outcome measure [Hoyles RK et al. Arthritis Rheum 2006; Tashkin DP et al. N Engl J Med 2006]. This article discusses the development of a composite outcome measure to assess treatment response in patients with SSc—ILD in clinical studies, and to create a more comprehensive measure than FVC% alone.