PT  - JOURNAL ARTICLE
AU  - Mosley, Mary
ED  - Gashouta, Mohamed A.
TI  - Initial Combination Therapy Improves Hemodynamics and Function in Scleroderma PAH
DP  - 2014 Sep 01
TA  - MD Conference Express
PG  - 13--13
VI  - 14
IP  - 11
4099  - http://mdc.sagepub.com/content/14/11/13.1.short
4100  - http://mdc.sagepub.com/content/14/11/13.1.full
AB  - Patients with systemic sclerosis pulmonary arterial hypertension (SSc-PAH) have a worse prognosis than those with idiopathic PAH. Although the specific mechanisms are not known, it is thought to be related to persistent right ventricular dysfunction and pulmonary vascular remodeling despite guideline-directed management with a single agent for PAH. This article discusses a 36-week, open-label, multicenter observational study evaluating upfront therapy with 2 drugs, tadalafil and ambrisentan, that target distinct pathways in treatment-naïve patients with SSc-PAH [NCT01178073; Gashouta MA et al. Am J Respir Crit Care Med].