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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EAMG 157 is a human antithymic stromal lymphopoietin (TSLP) monoclonal immunoglobulin-2? molecule that blocks the interaction between TSLP and its receptor, a process that is thought to be important in initiating allergic inflammation. This article presents data from the Double-Blind, Multiple Dose Study in Subjects With Mild Atopic Asthma study [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01405963\u0026amp;atom=%2Fspmdc%2F14%2F11%2F9.atom\u0022\u003ENCT01405963\u003C\/a\u003E; Gauvreau GM et al. \u003Cem\u003EAm J Crit Care Med\u003C\/em\u003E 2014].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EAsthma\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPulmonary Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EPulmonary \u0026amp; Respiratory Medicine\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EAMG 157 is a human antithymic stromal lymphopoietin (TSLP) monoclonal immunoglobulin-2\u03b3 molecule that blocks the interaction between TSLP and its receptor, a process that is thought to be important in initiating allergic inflammation. Gail M. Gauvreau, PhD, McMaster University, Hamilton, Ontario, Canada, presented data from the Double-Blind, Multiple Dose Study in Subjects With Mild Atopic Asthma study [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01405963\u0026amp;atom=%2Fspmdc%2F14%2F11%2F9.atom\u0022\u003ENCT01405963\u003C\/a\u003E; Gauvreau GM et al. \u003Cem\u003EAm J Crit Care Med\u003C\/em\u003E 2014] evaluating whether the AMG 157 monoclonal antibody reduced baseline airway inflammation and allergen-induced bronchoconstriction as measured by early (6-week) and late (12-week) asthmatic responses (EAR and LAR, respectively) to allergen challenge in subjects with mild allergic asthma.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EEligible patients had mild asthma and responded to an inhaled allergen challenge with EAR and LAR during screening, which determined the concentration of the allergen challenge. Subjects were randomized in a 1:1 ratio to AMG 157 (n=16) or placebo (n=15). Patients were treated on Days 1, 29, and 57 (700-mg intravenous infusion) and were given an allergen challenge on Days 42 and 84. Induced sputum was collected 1 day before and 7 and 24 hours after each allergen challenge, and methacholine airway responsiveness was measured 1 day before and 1 day after each allergen challenge.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe baseline characteristics are detailed in \u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/14377\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/14377\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14377\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EBaseline Characteristics in Study Patients\u003Csup\u003E\u003Csup\u003Ea\u003C\/sup\u003E\u003C\/sup\u003E\n            \u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-9\u0022\u003EThere was a trend toward improvement in the primary end point, LAR between 3 and 7 hours after the allergen challenge as measured by maximum percentage decrease in forced expiratory volume in 1 second at 6 weeks for AMG 157 compared with placebo (14.9% vs 22.5%; treatment difference, 7.65; 95% CI, \u22121.30 to 16.60; p=0.09) and a significant improvement at 12 weeks (11.7% vs 21.6%, p=0.02). There was a trend toward improvement in a secondary end point, EAR between 0 and 2 hours after the allergen challenge using the same measure at 6 weeks (23.3% vs 31.8%; treatment difference, 8.57; 95% CI, 0.01 to 17.13; p=0.05) and 12 weeks (22.7% vs 32.9%; treatment difference, 10.27; 95% CI, \u22120.46 to 21; p=0.06) for AMG 157 compared with placebo.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EExploratory analyses revealed that the increases in blood eosinophil (p=0.004) and sputum eosinophil (p=0.015) levels were less with AMG 157 compared with placebo. Also, fractional exhaled nitric oxide, a surrogate marker of inflammation, was significantly reduced with AMG 157 treatment versus placebo (p=0.002). The number of adverse events was similar between treatments (15 in the AMG 157 group and 12 in the placebo group).\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EProf. Gauvreau highlighted the unexpected reductions in inflammatory markers (blood and sputum eosinophil counts and fractional exhaled nitric oxide) with AMG 157 versus placebo before the allergen challenge, suggesting that TSLP is constitutively expressed in the airway in the setting of asthma, even in the absence of allergen exposure. She suggested that the findings support a role for targeting TSLP to control both persisting airway inflammation and allergen-induced airway responses in individuals with allergic asthma.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/11\/9.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp1rp\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzp1rp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}