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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ESystolic daytime ambulatory blood pressure (BP) was significantly decreased by renal denervation plus standardized medical treatment with the Symplicity catheter compared with standardized medical treatment alone in patients with confirmed resistant hypertension. This article presents 6-month data from the multicenter Renal Denervation in Hypertension study [DENER-HTN; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01570777\u0026amp;atom=%2Fspmdc%2F14%2F18%2F14.atom\u0022\u003ENCT01570777\u003C\/a\u003E].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERenal Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertension \u0026amp; Kidney Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERenal Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertension \u0026amp; Kidney Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology \u0026amp; Cardiovascular Medicine\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ESystolic daytime ambulatory blood pressure (BP) was significantly decreased by renal denervation plus standardized medical treatment with the Symplicity catheter compared with standardized medical treatment alone in patients with confirmed resistant hypertension. Michel Azizi, MD, PhD, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France, presented 6-month data from the multicenter Renal Denervation in Hypertension study [DENER-HTN; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01570777\u0026amp;atom=%2Fspmdc%2F14%2F18%2F14.atom\u0022\u003ENCT01570777\u003C\/a\u003E]\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe Symplicity catheter system delivers radiofrequency energy to target nerves through the renal artery wall to reduce sympathetic nervous system involvement in hypertension [Medtronic 2013]. The purpose of the open-label DENER-HTN trial was to evaluate the safety, efficacy, and cost-effectiveness of renal denervation with the single-electrode Symplicity catheter for patients with resistant hypertension.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn the parallel superiority DENER-HTN trial, 106 patients with resistant hypertension were randomly assigned to receive renal denervation or 4 weeks of standardized therapy alone, after 4 weeks of standardized therapy did not reduce BP to \u0026lt;135\/85 mm Hg. Resistant hypertension was defined as office BP of 140\/90 mm Hg despite stable antihypertensive therapy with \u22653 medications. All patients received new, standardized treatment for hypertension that included indapamide (1.5 mg), ramipril (10 mg, or irbesartan, if cough present), and amlodipine (10 mg) daily.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe primary endpoint of the trial was changes in daytime ambulatory systolic BP at 6 months. At baseline, the mean office BP was 163\/95 mm Hg, and the daytime ambulatory BP was 153.9\/93.0 mm Hg. The mean body mass index was 30.1 kg\/m\u003Csup\u003E2\u003C\/sup\u003E, and the mean glomerular filtration rate was 88.6 mL\/minute. Patients were monitored with home BP; if the home BP was not \u0026lt;135\/85 mm Hg at 2 months, then the patient received spironolactone (25 mg) daily. If BP was still not controlled by 3, 4, or 5 months, patients also received bisoprolol, prazosin, and rilmenidine, respectively.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EPatients who underwent renal denervation experienced a significant decrease in systolic BP of 16 mm Hg and the treatment-only group experienced a decrease of 10 to 14 mm Hg, with a difference between the 2 arms of \u22125.9 mm Hg at 6 months (95% CI, \u221211 to \u22120.05; p=0.03). In addition, nighttime ambulatory BP decreased by 6 mm Hg. The proportion of patients who achieved BP \u0026lt;135\/85 mm Hg at 6 months was 42% in the renal denervation arm compared with 28% in the standardized treatment only arm; however, this was not significant. In both arms of the study at 6 months, \u0026gt;85% of patients required \u22654 antihypertensive agents, with about 30% requiring 7 antihypertensives.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EDr. Azizi concluded by stating that data from the DENER-HTN trial show that renal denervation with the Symplicity catheter results in a significant reduction in systolic daytime ambulatory BP in patients with resistant hypertension.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/18\/14.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp1b3\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}