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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EFimasartan reduced blood pressure (BP) and albumin-creatinine ratio (ACR) in patients with or without metabolic syndrome; however, patients with metabolic syndrome at baseline and 3 months were at a greater risk of elevated ACR at 1 year. This article presents 3-month and 1-year data from a 3-year multicenter study designed to evaluate the effect of early correction of metabolic syndrome on organ damage for patients with hypertension [K-METS]. The design of this study has been published [Kim C et al. \u003Cem\u003EPulse\u003C\/em\u003E 2013].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiometabolic Disorder\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiometabolic Disorder\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EFimasartan reduced blood pressure (BP) and albumin-creatinine ratio (ACR) in patients with or without metabolic syndrome; however, patients with metabolic syndrome at baseline and 3 months were at a greater risk of elevated ACR at 1 year. Jeong Bae Park, MD, Cheil General Hospital, Kwandong, Korea, presented-3-month and 1-year data from a 3-year multicenter study designed to evaluate the effect of early correction of metabolic syndrome on organ damage for patients with hypertension [K-METS]. The design of this study has been published [Kim C et al. \u003Cem\u003EPulse\u003C\/em\u003E 2013].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe antihypertensive agent fimasartan is derived from losartan and is expected to have greater efficacy and potency [Kim TW et al. \u003Cem\u003EBioorg Med Chem Lett\u003C\/em\u003E 2012]. In clinical trials of fimasartan, risk of cardiovascular disease was reduced with the correction of metabolic risk factors in addition to BP control. The purpose of the observational K-METS study was to determine the effect of the early correction of metabolic syndrome on organ damage, as well as the future development of diabetes and cardiovascular disease, for patients with hypertension.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn the prospective single-arm K-METS study, 5481 patients with hypertension received open-label fimasartan and are being followed for 3 years. At baseline, 17% of patients had diabetes, mean weight was 67.3 kg, mean body mass index was 25.3 kg\/m\u003Csup\u003E2\u003C\/sup\u003E, and the mean number of years taking an antihypertensive agent was 3.58. Baseline systolic and diastolic BPs (SBP and DBP, respectively) were 144 and 88 mm Hg, respectively. Metabolic syndrome was present in 57% of the study population.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe primary end point of the K-METS study is cardiovascular mortality, stroke, myocardial infarction, hospitalization for heart failure, and the development of diabetes at 3 years. At 3 months, patients with hypertension or metabolic syndrome received therapy for correction. At 1 year, BP, insulin resistance, diabetes, and cardiovascular events were assessed. At 3 years, incidence of diabetes and cardiovascular disease will be evaluated. Patients were categorized into 4 groups according to the presence of metabolic syndrome:\u003C\/p\u003E\u003Col class=\u0022list-ord \u0022 id=\u0022list-1\u0022\u003E\u003Cli id=\u0022list-item-1\u0022\u003E\n            \u003Cp id=\u0022p-6\u0022\u003E\n               \u003Cem\u003EGroup 1:\u003C\/em\u003E metabolic syndrome at baseline and 3 months\u003C\/p\u003E\n         \u003C\/li\u003E\u003Cli id=\u0022list-item-2\u0022\u003E\n            \u003Cp id=\u0022p-7\u0022\u003E\n               \u003Cem\u003EGroup 2:\u003C\/em\u003E metabolic syndrome at baseline but not at 3 months\u003C\/p\u003E\n         \u003C\/li\u003E\u003Cli id=\u0022list-item-3\u0022\u003E\n            \u003Cp id=\u0022p-8\u0022\u003E\n               \u003Cem\u003EGroup 3:\u003C\/em\u003E no metabolic syndrome at baseline but metabolic syndrome developed by 3 months\u003C\/p\u003E\n         \u003C\/li\u003E\u003Cli id=\u0022list-item-4\u0022\u003E\n            \u003Cp id=\u0022p-9\u0022\u003E\n               \u003Cem\u003EGroup 4:\u003C\/em\u003E no metabolic syndrome at baseline or 3 months\u003C\/p\u003E\n         \u003C\/li\u003E\u003C\/ol\u003E\u003Cp id=\u0022p-10\u0022\u003EAt 1 year, SBP and DBP significantly decreased to 127 and 79 mm Hg, respectively (p\u0026lt;0.0001), as well as ACR from 41.2 to 26.6 mg\/g (p\u0026lt;0.0001). The proportion of patients with metabolic syndrome also decreased to 44% (p\u0026lt;0.0001). Although all groups experienced a decrease in ACR, patients in Group 1 or 2 experienced the greatest decrease in ACR. Patients in Group 1 had the highest ACR rates compared with Groups 2, 3, and 4. In addition, patients in Group 1 were at a greater risk of ACR \u226530 mg\/g compared with Groups 2, 3, and 4 (odds ratio, 1.62; 95% CI, 1.33 to 1.97).\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EDr. Park stated that data from the K-METS trial suggest that fimasartan treatment results in a substantial decrease in BP and ACR at 3 months and 1 year.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/18\/13.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp1b3\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}