RT Journal Article SR Electronic A1 Hoyle, Brian T1 Mechanisms of Salt-Sensitive Hypertension JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 18 SP 4 OP 5 DO 10.1177/155989771418001 UL http://mdc.sagepub.com/content/14/18/4.abstract AB This article discusses the mechanisms of salt-sensitive hypertension. The link between salt intake and hypertension is not a recent discovery but, rather, has been known for a half-century on the basis of studies conducted worldwide. Subjects with hypertension can be classified as salt-insensitive and salt-sensitive. It is beginning to be understood that salt sensitivity can be modulated by multiple mechanisms, including the renal sympathetic nervous system, the mineralocorticoid receptor, and aldosterone.