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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EMenopause-associated bone loss begins during perimenopause, \u223c?2 years before the last menstrual period. This article presents data from the Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Alendronate on Bone Mineral Density and Bone Turnover in Perimenopausal Women With Low BMD poster [ICE\/ENDO 2014. Poster LBSA-0269], first study to evaluate the efficacy of an antiresorptive agent on maintaining BMD in perimenopausal women.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Emetabolic bone disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Emenopause\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ediabetes \u0026amp; endocrinology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EAlendronate plus cholecalciferol treatment improved bone mineral density (BMD) at the lumbar spine and reduced bone turnover in perimenopausal women with low BMD. Aliya Khan, MD, McMaster University, Hamilton, Ontario, Canada, presented data in a poster from the Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Alendronate (ALN) on Bone Mineral Density (BMD) and Bone Turnover in Perimenopausal Women With Low BMD [ICE\/ENDO 2014. Poster LBSA-0269].\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EMenopause-associated bone loss begins during perimenopause, \u223c 2 years before the last menstrual period. The purpose of this study was to determine if treatment with alendronate (ALN), an antiresorptive agent, can prevent bone loss in women who are perimenopausal and have low BMD. This is the first study to evaluate the efficacy of an antiresorptive agent on maintaining BMD in perimenopausal women.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EIn this double-blind trial, women aged 40 to 55 years with reduced bone density (T-score \u0026lt; \u22121.0) of the lumbar spine, total hip, or femoral neck were randomly assigned to receive 70 mg of ALN plus 2800 IU of cholecalciferol (vitamin D3) once weekly or placebo for 1 year. In addition, all patients received 500 mg of calcium carbonate once daily. Patients were eligible if they had at least 5 menstrual periods per year and had follicle-stimulating hormone (FSH) levels \u0026gt; 20 IU\/L but \u0026lt; 40 IU\/L on 2 independent occasions. Patients were excluded if they had hyperthyroidism, hyperparathyroidism, liver disease, acromegaly, Cushing syndrome, rheumatoid arthritis, myeloma, Paget disease, renal osteodystrophy, osteomalacia, or polycystic ovarian disease. Other exclusion criteria included treatment during the past 6 months with androgens, calcitonin, systemic corticosteroids, fluoride, parathyroid hormone, selective estrogen receptor modulators, estrogen, oral contraceptives, bisphosphates, vitamin D \u0026gt; 2000 IU per day, or vitamin D metabolites. In addition, patients with esophageal abnormalities, including stricture or achalasia, were excluded from the study.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EAt 12 months, there was a significant increase in BMD at the lumbar spine (L1 to L4; 3.66%; p \u0026lt; .01) and a trend of increased BMD at the femoral neck (2.07%; p = .14) from baseline among patients who received ALN plus cholecalciferol compared with placebo (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). In addition, there was a significant decrease in bone-specific alkaline phosphatase (\u221237.8%; p \u0026lt; .01) and N-telopeptide in the urine (27.2%; p = .03) and an increase in FSH (101.13%; p \u0026lt; .01), as well as a trend of decreased N-telopeptide in the serum (\u221227.6%; p = .23), from baseline in the ALN arm compared with the placebo arm. Treatment with ALN plus cholecalciferol resulted in no significant difference from baseline compared with placebo in albumin, calcium, phosphate, magnesium, estradiol, or urine creatinine.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/20\/10\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Effect of Alendronate on BMD in Perimenopausal Women\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-160926832\u0022 data-figure-caption=\u0022Effect of Alendronate on BMD in Perimenopausal Women\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/20\/10\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/20\/10\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/20\/10\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/16426\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EEffect of Alendronate on BMD in Perimenopausal Women\u003C\/p\u003E\n            \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EBMD=bone mineral density.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003EReproduced with permission from A Khan, MD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EIn conclusion, treatment of perimenopausal women with low BMD with ALN plus cholecalciferol reduced bone turnover and improved BMD in the lumbar spine over 12 months. Prof. Khan indicated that the data from this study suggest that providing early intervention with a bisphosphonate during the menopausal transition may limit BMD loss.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/20\/10.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzoyap\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzoyap\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}