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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EVarious dietary elements have been linked to the development of colorectal cancer (CRC). In addition, factors like blood lipids could affect how dietary fats contribute to the development of CRC [Kato I et al. \u003Cem\u003EInt J Cancer\u003C\/em\u003E 2010; Endo H et al. \u003Cem\u003EGut\u003C\/em\u003E 2009]. This article presents the use of data from the Rotterdam Study to determine whether intake of polyunsaturated fatty acids and saturated fatty acids is associated with CRC and whether it is affected by levels of dietary fiber or blood lipids [Kraja B et al. \u003Cem\u003EAnn Oncol\u003C\/em\u003E 2014 (abstr O-0013)].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ELipid Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ELipid Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EVarious dietary elements have been linked to the development of colorectal cancer (CRC). It is not known, however, if or how dietary fat components (eg fatty acids) contribute to this disease. In addition, factors like blood lipids could affect how dietary fats contribute to the development of CRC [Kato I et al. \u003Cem\u003EInt J Cancer\u003C\/em\u003E 2010; Endo H et al. \u003Cem\u003EGut\u003C\/em\u003E 2009].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EBledar Kraja, MD, PhD, Erasmus Medical Center, Rotterdam, The Netherlands, presented the use of data from the Rotterdam Study to determine whether intake of polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) is associated with CRC and whether it is affected by levels of dietary fiber or blood lipids [Kraja B et al. \u003Cem\u003EAnn Oncol\u003C\/em\u003E 2014 (abstr O-0013)].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe Rotterdam Study, a single-center, population-based, prospective cohort study that enrolled 7983 adults aged \u2265 55 years in a suburb of Rotterdam, The Netherlands, examined the incidence of, prevalence of, and risk factors for chronic disease in the elderly with the objective of improved prevention and treatment. Researchers obtained baseline measurements from 1990 to 1993, and follow-up measurements every 2 to 3 years for the original cohort. In 2000, 3011 subjects aged \u2265 55 years were added; in 2006, 3932 subjects aged \u2265 45 years were added. All subjects are reexamined every 3 to 4 years. The total Rotterdam Study population includes 14,926 participants [Hofman A et al. \u003Cem\u003EEur J Epidemiol\u003C\/em\u003E 2013]. The cohorts and examination cycles are shown in \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/22\/12.2\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022The Rotterdam Study\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-842807046\u0022 data-figure-caption=\u0022The Rotterdam Study\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/22\/12.2\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/22\/12.2\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/22\/12.2\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14853\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EThe Rotterdam Study\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003ERS=Rotterdam Study; RS1=baseline examination of original cohort; RS2, RS3, and RS4=reexaminations of the original cohort; RSPlus1=extension of the cohort with individuals in the study district who became age 55 years since the start of the study or those age 55 years or older who migrated into the study district; RSPlus2=reexamination of the extension cohort; RSYoung1=baseline examination of all individuals age 45 years or older living in the study district who had not been examined.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003EHofman A et al. The Rotterdam Study: objectives and design update. \u003Cem\u003EEur J Epidemiol\u003C\/em\u003E. 2007; 22: 819\u2013829. With permission from Springer Publishing Company.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-6\u0022\u003EDr. Kraja\u0027s group looked at data from 4902 subjects aged \u2265 55 years from the first cohort of the Rotterdam Study. Diet was determined by a food frequency questionnaire. CRC was classified using the 10th edition of the International Classification of Diseases. Cox regression models were used to calculate multivariable adjusted hazard ratios (HRs).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EIncident cases of CRC (n = 218) were identified during a follow-up of 24 years. No evidence of an association between PUFAs intake and CRC was seen. A positive linear relationship was evident, however, between SFAs intake and CRC (HR, 1.02; 95% CI, 1.01 to 1.03). In participants with high dietary-fiber intake (\u0026gt; median), PUFAs intake was associated with an increased risk of CRC (HR, 2.12; 95% CI, 1.04 to 4.29 for the 4th quartile vs the 1st quartile). Among those participants with low fiber intake (\u0026lt; median), SFAs intake was associated with higher CRC risk (HR, 1.52; 95% CI, 1.12 to \u22122.06 for the 4th quartile vs the 1st quartile). In contrast, a negative linear relationship was observed between SFAs intake and CRC (HR, 0.97; 95% CI, 0.95 to 0.995) among participants with high fiber intake. An increased risk of CRC in participants with low serum cholesterol was associated with a higher PUFAs intake (p \u003Cem\u003Einteraction\u003C\/em\u003E = .01 for n-3 PUFA and fiber intake; p \u003Cem\u003Einteraction\u003C\/em\u003E = .05 for n-6 PUFAs and serum cholesterol).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EAlthough data from this study suggest that dietary fat intake interacts with dietary fiber and blood lipids to increase the risk of CRC, further investigation is required to determine how other dietary and nondietary factors affect this risk.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/22\/12.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzoxlp\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzoxlp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}