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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ESecreted protein acidic and rich in cysteine (SPARC) protein expression levels were not associated with overall survival (OS) or progression-free survival (PFS) in patients with metastatic pancreatic cancer from the Phase 3 Study of ABI-007 (Albumin-Bound Paclitaxel) plus Gemcitabine Versus Gemcitabine in Metastatic Adenocarcinoma of the Pancreas trial [MPACT; Hidalgo M et al. \u003Cem\u003EAnn Oncol\u003C\/em\u003E 2014 (abstr O-0003)]. This article presents data from a subanalysis of the MPACT trial.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ESecreted protein acidic and rich in cysteine (SPARC) protein expression levels were not associated with overall survival (OS) or progression-free survival (PFS) in patients with metastatic pancreatic cancer from the Phase 3 Study of ABI-007 (Albumin-Bound Paclitaxel) plus Gemcitabine Versus Gemcitabine in Metastatic Adenocarcinoma of the Pancreas trial [MPACT; Hidalgo M et al. \u003Cem\u003EAnn Oncol\u003C\/em\u003E 2014 (abstr O-0003)]. Manuel Hidalgo, MD, PhD, Centro Nacional de Investigaciones Oncol\u00f3gicas, Madrid, Spain, presented data from a sub-analysis of the MPACT trial.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EPrevious studies have suggested that increased expression of SPARC is correlated with decreased OS in patients with resectable pancreatic cancer [Infante JR et al. \u003Cem\u003EJ Clin Oncol\u003C\/em\u003E 2007]. In addition, a Phase 1\/2 trial demonstrated that lower levels of SPARC were significantly associated with prolonged OS (p = .043) [Von Hoff DD et al. \u003Cem\u003EJ Clin Oncol\u003C\/em\u003E 2011]. The purpose of this sub-analysis of the MPACT trial was to further evaluate the relationship between SPARC and metastatic pancreatic cancer outcomes.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EFor this analysis, stromal fibroblasts and tumor epithelia harvested from predominantly metastatic lesion were assessed for SPARC levels using immunohistochemistry (IHC) with an anti-SPARC monoclonal antibody that was scored by 2 blinded pathologists [Hidalgo M et al. \u003Cem\u003EAnn Oncol\u003C\/em\u003E 2014 (abstr O-0003)]. Stromal SPARC levels were considered high if \u2265 50% of fibroblasts stained positive. Tumor SPARC was measured assessing the histoscore, a well-established method for scoring protein expression in tissue that has heterogeneous staining in cell membranes, cytoplasm, and cell nuclei. Tumor SPARC was considered high if the histoscore was \u2265 100 and negative if the histoscore was 0. Enzyme-linked immunosorbent assay was used to evaluate SPARC levels in plasma collected at baseline and every 8 weeks in the MPACT trial. The IHC assay demonstrated 86% concordance between the Phase 1\/2 and MPACT trials, and stromal SPARC was evaluable in 30% of patients from the MPACT trial.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EStromal SPARC expression was high in 71 out of 256 samples and was not associated with OS (HR, 1.019; p .903). In addition, tumor epithelial SPARC, which was low or negative in most samples, was also not associated with OS. Evaluable in 40% of patients, plasma SPARC levels were not significantly different between baseline and time points, and they were no associated with OS. PFS was not associated with SPARC expression levels in any of the samples.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EIn conclusion, Prof. Hidalgo indicated that, in his opinion, the data from this analysis of the MPACT trial suggest that SPARC expression was not prognostic for OS and was not predictive of treatment response in patients with metastatic pancreatic cancer. Therefore, SARC analysis requires further study and is not yet recommended to be used for treatment decisions in patient population.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/22\/11.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzoxlp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}