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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EInhaled nitric oxide (NO) did not reduce infarct size (IS) in patients who experienced STEMI and underwent percutaneous coronary intervention (PCI). This article presents data from the Effects of Nitric Oxide for Inhalation in Myocardial Infarction Size study [NOMI; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01398384\u0026amp;atom=%2Fspmdc%2F14%2F27%2F24.1.atom\u0022\u003ENCT01398384\u003C\/a\u003E].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMyocardial Infarction\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMyocardial Infarction\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EInhaled nitric oxide (NO) did not reduce infarct size (IS) in patients who experienced STEMI and underwent percutaneous coronary intervention (PCI). Stefan P. Janssens, MD, PhD, University of Leuven, Leuven, Belgium, presented data from the Effects of Nitric Oxide for Inhalation in Myocardial Infarction Size study [NOMI; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01398384\u0026amp;atom=%2Fspmdc%2F14%2F27%2F24.1.atom\u0022\u003ENCT01398384\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn animal models, inhalation of 40 to 80 ppm of NO decreased IS and area at risk and improved functional recovery [Liu X et al. \u003Cem\u003EJ Am Coll Cardiol.\u003C\/em\u003E 2007; Hataishi R et al. \u003Cem\u003EAm J Physiol Heart Circ Physiol.\u003C\/em\u003E 2006]. The hypothesis of the NOMI study was that inhaled NO would decrease IS and improve left ventricular (LV) function in patients with STEMI who underwent primary PCI.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe NOMI trial was a multicenter double-blind phase 2 trial that randomized 248 patients with STEMI undergoing PCI within 12 hours to either inhaled NO (80 ppm) or placebo. All patients underwent magnetic resonance imaging to evaluate IS, LV function, and remodeling at 48 to 72 hours and again at 4 months. The primary end point was IS and secondary end points included myocardial salvage index, myocardial hemorrhage, LV remodeling at 48 to 72 hours, and LV remodeling at 4 months. The trial also examined the effects on prespecified subgroups, including TIMI flow grade, culprit artery, time between symptom onset and PCI, and troponin levels upon admission.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EInhaled NO failed to significantly reduce IS, and the IS\/LV mass ratio was 19.4% in the control arm and 18% in the inhaled NO arm (estimate R effect, \u22121.48; 95% CI, \u22125.25 to 2.29; \u003Cem\u003EP\u003C\/em\u003E = .44). There were no differences in the composite end point of death, recurrent ischemia, stroke, and rehospitalization at 150 days (log-rank \u003Cem\u003EP\u003C\/em\u003E = .1022). NO treatment resulted in a significant improvement in LV remodeling at 4 months (OR, 0.90; 95% CI, 0.81 to 0.999; \u003Cem\u003EP\u003C\/em\u003E = .048) compared with control. There were no significant differences in the other secondary end points.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EProf Janssens stated that the data from the NOMI trial show that inhaled NO is safe but did not decrease the IS, as measured by percentage LV mass. However, there were improvements in LV remodeling at 4 months.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/27\/24.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzoud2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}