PT  - JOURNAL ARTICLE
AU  - Mosley, Mary
ED  - Fox, Kim
TI  - SIGNIFY: Treatment with Ivabradine Does Not Improve Outcomes and May Increase Risk in Patients with Angina
DP  - 2014 Nov 01
TA  - MD Conference Express
PG  - 13--14
VI  - 14
IP  - 27
4099  - http://mdc.sagepub.com/content/14/27/13.short
4100  - http://mdc.sagepub.com/content/14/27/13.full
AB  - This article presents the results of the Study Assessing the Morbidity-Mortality Benefits of the If Inhibitor Ivabradine in Patients With Coronary Artery Disease Without Heart Failure [SIGNIFY; Fox K et al. N Engl J Med. 2014]. The study found that treatment with ivabradine did not reduce the risk of cardiovascular (CV) death or nonfatal myocardial infarction (NFMI). However, in patients with Canadian Cardiovascular Society class II or greater angina at baseline, ivabradine increased the risk of CV death or myocardial infarction.