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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EResults from ABSORB II [Serruys PW et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2014], the first study to compare an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent, demonstrated similar 1-year clinical outcomes in patients with coronary artery disease.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EResults from ABSORB II [Serruys PW et al. \u003Cem\u003ELancet\u003C\/em\u003E. 2014], the first study to compare an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent, demonstrated similar 1-year clinical outcomes in patients with coronary artery disease. Data were presented by Patrick W. Serruys, MD, Imperial College, London, United Kingdom.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EABSORB II is an ongoing, randomized, single-blind, multicenter clinical investigation comparing clinical and procedural outcomes between the ABSORB everolimus-eluting bioresorbable vascular scaffold system and the everolimus-eluting coronary stent (XIENCE). The coprimary end points are vasomotion (change in mean lumen diameter before and after nitrate administration at 3 years) and the difference between minimum lumen diameter (after nitrate administration) after the index procedure and at 3 years. Prof Serruys presented the secondary clinical and procedural outcomes; a composite clinical end point of death, myocardial infarction (MI), and coronary revascularization; device and procedural success; and angina status.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EABSORB-II included patients (n = 501) aged 18 to 85 years with evidence of myocardial ischemia and up to 2 de novo native lesions in different epicardial vessels randomized to either the ABSORB scaffold (n = 335) or XIENCE stent (n = 166). Procedural performance was assessed by quantitative angiography and intravascular ultrasound (IVUS). Device and procedural success were presented in percentage. Angina status was assessed by the Seattle Angina Questionnaire (SAQ). Exercise testing occurred at 6 and 12 months. Post hoc adverse event (AE) reporting was used to determine cumulative angina rate.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EApproximately 84% of patients had single vessel disease, of which the majority (98%) was class B1\/B2 lesions. There were no differences in procedural details per lesion except for nominal diameter of last balloon used (ABS ORB 3.08 mm vs XIENCE 3.16 mm; \u003Cem\u003EP\u003C\/em\u003E = .02) and maximum last balloon pressure used (ABSORB 14.23 atm vs XIENCE 15.03 atm; \u003Cem\u003EP\u003C\/em\u003E = .01).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EClinical device and procedural success rates for both devices were \u0026gt; 95%. There was no difference in the cumulative incidence of the composite clinical outcome of death, MI, or revascularization (7% and 9% ABSORB and XIENCE arms, respectively; \u003Cem\u003EP\u003C\/em\u003E = .47). Acute lumen gain whether by angiography (ABSORB 1.15 mm vs XIENCE 1.46 mm) or IVUS (Absorb 2.85 mm\u003Csup\u003E2\u003C\/sup\u003E, XIENCE 3.60 mm\u003Csup\u003E2\u003C\/sup\u003E) was significantly (both \u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001) lower in the ABSORB arm compared with the XIENCE arm. The investigators suggested this may be attributable to the greater pressure and larger size of balloon used during the postimplantation dilatation with XIENCE.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EOne definite acute, 1 definite subacute, and 1 probable late incidence of scaffold thrombosis was documented in the ABSORB arm and none in the XIENCE arm. The per-protocol periprocedural MI rates were 4% and 1% in the ABSORB and XIENCE arms (\u003Cem\u003EP\u003C\/em\u003E = .16), respectively. There were 17 (5%) major cardiac AEs with ABSORB compared with 5 (3%) events in the XIENCE arm. The most common AEs were MI and target-lesion revascularization. Myocardial biomarkers (troponin, creatine kinase, creatine kinase-MB) did not indicate a substantial difference in myonecrosis between the 2 devices.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EExercise performance and angina status as assessed by SAQ were comparable (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). Cumulative rates of new, recurrent, or worsening angina were lower in the ABSORB (21.8%) group compared with the XIENCE (30.5%) group (\u003Cem\u003EP\u003C\/em\u003E = .04). If the first 7 days including hospitalization were excluded, the rates were 16.4% and 25.6% (\u003Cem\u003EP\u003C\/em\u003E = .02). This post hoc, hypothesis-generating observation warrants further physiological and clinical investigation.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/30\/10\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022SAQ Exercise Performance and Angina Status\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1982183373\u0022 data-figure-caption=\u0022SAQ Exercise Performance and Angina Status\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/30\/10\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/30\/10\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/30\/10\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11874\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-9\u0022 class=\u0022first-child\u0022\u003ESAQ Exercise Performance and Angina Status\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003E*\u003Cem\u003EP\u003C\/em\u003E value from post hoc t test; **\u2020\u003Cem\u003EP\u003C\/em\u003E value from post hoc \u03c7\u003Csup\u003E2\u003C\/sup\u003E test.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003ESAQ, Seattle Angina Questionnaire.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-3\u0022\u003EReproduced from Serruys PW et al. A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomized controlled trial. \u003Cem\u003ELancet\u003C\/em\u003E. 14 Sept 2014; In Press, Corrected Proof. Copyright 2014, with permission from Elsevier.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/30\/10.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzosz1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzosz1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}