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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EGlucagon-like peptide 1 agonists have been shown to improve glycemic control and reduce the risk of weight gain and hypoglycemia, but some patients have gastrointestinal (GI) side effects. Basal insulin offers glycemic control even while fasting and allows for individualized dosing but increases the risk of hypoglycemia and weight gain. This article discusses 1-year safety and efficacy data from the phase 3, open-label Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec\/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes [DUAL I].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHyperglycemia\/Hypoglycemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHyperglycemia\/Hypoglycemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EEndocrinology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Metabolic Syndrome\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EGlucagon-like peptide 1 agonists have been shown to improve glycemic control and reduce the risk of weight gain and hypoglycemia, but some patients have gastrointestinal (GI) side effects. Basal insulin offers glycemic control even while fasting and allows for individualized dosing but increases the risk of hypoglycemia and weight gain. Combining these 2 agents has many potential advantages, such as improving glycemic control and reducing weight gain, while also reducing the risk of hypoglycemia or GI side effects seen when either agent is used as monotherapy. IDegLira is one such agent and contains a fixed-ratio combination of insulin degludec (IDeg) and liraglutide. The drug contains 0.036 mg of liraglutide for every 1 unit of IDeg.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EStephen C. L. Gough, MD, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Oxford, United Kingdom, discussed 1-year safety and efficacy data from the phase 3, open-label Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec\/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes [DUAL I; Gough SCL et al. \u003Cem\u003ELancet Diabetes Endocrinol\u003C\/em\u003E. 2014].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPatients were randomly assigned 2:1:1 to IDegLira (n = 834), IDeg (n = 414), or liraglutide (n = 415). Baseline characteristics were similar for all groups. The average age was 55 years; body mass index was about 31 kg\/m\u003Csup\u003E2\u003C\/sup\u003E; HbA\u003Csub\u003E1c\u003C\/sub\u003E was 8.3%; and fasting plasma glucose (FPG) was about 9 mmol\/L.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EHbA\u003Csub\u003E1c\u003C\/sub\u003E was lower in the patients treated with IDegLira (6.4%) when compared with either the IDeg group (6.9%) or the liraglutide group (7.0%) at week 26 (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001 for IDegLira vs both other treatments). These reductions were maintained at 52 weeks (HbA\u003Csub\u003E1c\u003C\/sub\u003E = 6.4%, 6.9%, and 7.1%, respectively; \u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001 for IDegLira vs both other treatments). The percentages of patients whose HbA\u003Csub\u003E1c\u003C\/sub\u003E were \u0026lt; 7% or \u2264 6.5% at the end of weeks 26 and 52 were significantly greater in the group treated with IDegLira than in those treated with IDeg or liraglutide (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001, all).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe decrease in FGP was similar in the IDegLira and IDeg groups (\u22123.6 mmol\/L) and significantly lower when compared with the liraglutide group (\u22121.75 mmol\/L) at 26 weeks (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001). These decreases were maintained at 52 weeks, when FPG was 5.7, 6.0, and 7.3 mmol\/L, respectively. At both 26 and 52 weeks, confirmed hypoglycemia was lowest with liraglutide and highest with IDeg, although rates were low overall. There was a slight increase in weight with IDeg, a decrease with liraglutide, and a slight but significant decrease with IDegLira when compared with either treatment (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe rates of nausea in patients receiving IDeg and IDegLira were generally lower than they were for liraglutide. Other adverse events were similar across groups, and those for patients taking IDegLira were as expected for the individual components.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EIn conclusion, the DUAL I study showed that IDegLira was associated with significantly greater reductions in HbA\u003Csub\u003E1c\u003C\/sub\u003E, significantly lower risk of hypoglycemia, and no weight gain as compared with IDeg at 52 weeks. When compared with liraglutide, IDegLira had greater reductions in HbA\u003Csub\u003E1c\u003C\/sub\u003E and FPG while resulting in fewer GI adverse events. These data provide further support for the long-term safety and sustainability of the glucose-lowering effect of IDegLira.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/32\/22.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzorq2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}