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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EEmpagliflozin is superior to glimepiride as an add-on treatment option for patients with type 2 diabetes mellitus who have not achieved good glycemic control on metformin, according to results from the Efficacy and Safety of Empagliflozin (BI 10773) With Metformin in Patients With Type 2 Diabetes trial that are presented in this article.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EEndocrinology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Metabolic Syndrome\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EEmpagliflozin is superior to glimepiride as an add-on treatment option for patients with type 2 diabetes mellitus (T2DM) who have not achieved good glycemic control on metformin, according to results from the Efficacy and Safety of Empagliflozin (BI 10773) With Metformin in Patients With Type 2 Diabetes trial [Ridderstr\u00e5le M et al. \u003Cem\u003ELancet Diabetes Endocrinol\u003C\/em\u003E. 2014], announced lead investigator Martin Ridderstr\u00e5le, MD, Steno Diabetes Center, Gentofte, Denmark.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EMetformin represents traditional first-line therapy for patients with T2DM, but there is no consensus regarding optimal second-line treatment. According to Prof Ridderstr\u00e5le, empagliflozin is a selective sodium-glucose cotransporter 2 inhibitor, a new class of drugs for the management of T2DM, while glimepiride is a sulfonylurea.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThis phase 3 double-blind study aimed to compare the efficacy and safety of empagliflozin and glimepiride as second-line therapy in patients with T2DM who are not adequately controlled on metformin. The study included patients \u0026gt; 18 years with a body mass index \u2264 45 kg\/m\u003Csup\u003E2\u003C\/sup\u003E and with HbA\u003Csub\u003E1c\u003C\/sub\u003E levels between 7% and 10% who were on a stable background therapy of metformin for \u2265 12 weeks before randomization. The investigators excluded subjects with an estimated glomerular filtration rate \u0026lt; 60 mL\/min\/1.73 m\u003Csup\u003E2\u003C\/sup\u003E during screening or placebo run-in.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe researchers randomized participants (n = 1549) in a 1:1 ratio to oral empagliflozin (25 mg, QD) or oral glimepiride (1 to 4 mg, QD) as add-on to metformin for 104 weeks. The primary end point was the change from baseline in HbA\u003Csub\u003E1c\u003C\/sub\u003E levels at weeks 52 and 104 and included noninferiority and superiority criteria.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EFrom baseline to 104 weeks, patients treated with empagliflozin had significantly greater reductions in mean HbA\u003Csub\u003E1c\u003C\/sub\u003E levels when compared with patients treated with glimepiride. Empagliflozin was noninferior to glimepiride at baseline and 104 weeks. The adjusted mean difference in change from baseline in HbA\u003Csub\u003E1c\u003C\/sub\u003E with empagliflozin versus glimepiride was \u22120.11% (95% CI, \u22120.19 to \u22120.02; \u003Cem\u003EP\u003C\/em\u003E = .015 for superiority; see \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). The investigators also observed significant reductions with empagliflozin in body weight (\u22123.1 vs 1.3 kg; \u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001), systolic blood pressure (\u22123.1 vs 2.5 mm Hg; \u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001), and diastolic blood pressure (\u22121.8 vs 0.9 mm Hg; \u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001). The incidence of death was similar in the 2 groups (0.7% vs 0.6%).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/32\/12\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Change in Mean HbA1c From Baseline at 104 Weeks\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1072108286\u0022 data-figure-caption=\u0022\u0026amp;lt;div xmlns=\u0026amp;quot;http:\/\/www.w3.org\/1999\/xhtml\u0026amp;quot;\u0026amp;gt;Change in Mean HbA\u0026amp;lt;sub\u0026amp;gt;1c\u0026amp;lt;\/sub\u0026amp;gt; From Baseline at 104 Weeks\u0026amp;lt;\/div\u0026amp;gt;\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/32\/12\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/32\/12\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/32\/12\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12023\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EChange in Mean HbA\u003Csub\u003E1c\u003C\/sub\u003E From Baseline at 104 Weeks\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EReprinted from \u003Cem\u003EThe Lancet Diabetes \u0026amp; Endocrinology\u003C\/em\u003E, 2, Ridderstrale M et al, Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial, 691\u2013700, Copyright 2014, with permission from Elsevier.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-8\u0022\u003EEmpagliflozin was also associated with significantly fewer hypoglycemic adverse events (AEs) than glimepiride (24% vs 3%; \u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001). In the empagliflozin group, serious AEs were reported in 16% of patients, compared with 11% in the glimepiride group. The incidence of AEs leading to treatment discontinuation was similar in both groups (5% vs 4%). Urinary tract infection was recorded in 13.7% and 13.1% of patients receiving empagliflozin and glimepiride, respectively, and genital infection in 11.8% and 2.2% of patients, respectively.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EProf Ridderstr\u00e5le concluded that, compared with glimepiride, empagliflozin as add-on therapy to metformin produced a small but significantly superior difference in the reduction of HbA\u003Csub\u003E1c\u003C\/sub\u003E and provided sustained reductions in body weight and blood pressure. Patients treated with empagliflozin had fewer AEs, particularly hypoglycemia.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/32\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzorq2\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzorq2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}