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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article presents results from the Safety and Efficacy of Combination Saxagliptin \u0026amp; Dapagliflozin Added to Metformin to Treat Subjects With Type 2 Diabetes trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01606007\u0026amp;atom=%2Fspmdc%2F14%2F32%2F10.atom\u0022\u003ENCT01606007\u003C\/a\u003E]. This active-controlled, double-blind, parallel-group phase 3 study demonstrated that combined saxagliptin and dapagliflozin, when added to metformin, were more effective in reducing glucose than treatment with metformin alone in adults with type 2 diabetes mellitus.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHyperglycemia\/Hypoglycemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EEndocrinology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Metabolic Syndrome\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHyperglycemia\/Hypoglycemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EJulio Rosenstock, MD, Dallas Diabetes and Endocrine Center, Dallas, Texas, USA, presented results from the Safety and Efficacy of Combination Saxagliptin \u0026amp; Dapagliflozin Added to Metformin to Treat Subjects With Type 2 Diabetes trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01606007\u0026amp;atom=%2Fspmdc%2F14%2F32%2F10.atom\u0022\u003ENCT01606007\u003C\/a\u003E]. This active-controlled, double-blind, parallel-group phase 3 study demonstrated that combined saxagliptin and dapagliflozin, when added to metformin, were more effective in reducing glucose than treatment with metformin alone in adults with type 2 diabetes mellitus (T2DM).\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EAccording to Dr Rosenstock, the sequential addition of a single glycemic control agent is the recommended approach for T2DM patients who are poorly controlled on metformin monotherapy. However, this approach may be inadequate, particularly when HbA\u003Csub\u003E1c\u003C\/sub\u003E levels are significantly elevated.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe study aimed to investigate the efficacy and safety of early triple therapy that includes metformin and the concomitant initiation of dual oral therapy with the dipeptidyl peptidase 4 inhibitor saxagliptin and the sodium-glucose cotransporter 2 inhibitor dapagliflozin.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EPatients (n = 534) were randomized to saxagliptin \u22125 mg + dapagliflozin-10 mg + metformin (n = 179), saxagliptin-5 mg + metformin + placebo (n = 176), or dapagliflozin-10 mg + metformin + placebo (n = 179). The study enrolled adults (\u0026gt; 18 years) with a body mass index \u2264 45 kg\/m\u003Csup\u003E2\u003C\/sup\u003E, HbA\u003Csub\u003E1c\u003C\/sub\u003E levels \u2265 8% and \u2264 12%, and an estimated glomerular filtration rate \u2265 60 mL\/min\/1.73 m\u003Csup\u003E2\u003C\/sup\u003E. All participants were receiving \u2265 1500 mg\/d of metformin before randomization.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe primary end point was the adjusted mean change in baseline HbA\u003Csub\u003E1c\u003C\/sub\u003E levels at week 24. At 24 weeks, the reduction in mean HbA\u003Csub\u003E1c\u003C\/sub\u003E levels was significantly greater in patients treated with saxagliptin + dapagliflozin + metformin when compared with saxagliptin + metformin (\u22121.5% vs \u22120.9%; \u003Cem\u003EP\u003C\/em\u003E \u0026lt; .001) and dapagliflozin + metformin (\u22121.5% vs \u22121.2%; \u003Cem\u003EP\u003C\/em\u003E = .02;). Additionally, more patients in the saxagliptin + dapagliflozin + metformin group achieved a target HbA\u003Csub\u003E1c\u003C\/sub\u003E \u0026lt; 7% (41% vs 18% vs 22%).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003ENo deaths were reported in any of the groups. The incidence of serious adverse events (AEs) was similar in all 3 groups (1% vs 3% vs 1%). The incidence of AEs leading to treatment discontinuation was also similar (0.6% vs 0% vs 0%). With respect to AEs of special interest, the incidence of urinary tract infections was also similar in all 3 groups (0.6% vs 5% vs 4%), and the incidence of hypoglycemia was low (1% in all groups). Genital infections were not recorded in the saxagliptin + dapagliflozin + metformin group (0% vs 0.6% vs 6%).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EIn his concluding remarks, Dr Rosenstock stated that when compared with monotherapy, the addition of saxagliptin and dapagliflozin to metformin in poorly controlled TD2M patients led to greater reductions in HbA\u003Csub\u003E1c\u003C\/sub\u003E and allowed more patients to achieve a target HbA\u003Csub\u003E1c\u003C\/sub\u003E \u0026lt; 7%. Dual add-on therapy was also well tolerated and did not increase the risk of hypoglycemia in patients.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/32\/10.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzorq2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}